中国药房2017，Vol.28Issue(14)：1899-1903,5.DOI:10.6039/j.issn.1001-0408.2017.14.08
CFDA和FDA标准下我院精神专科药物超适应证使用比较分析
Comparison and Analysis about Off-indication Use of Psychiatric Drugs in Our Hospital by the Standards of CFDA and FDA
贾晓妮 1权伟 1陈建波 1岳丹萍 2支媗 1张晓红1
作者信息
- 1. 西安市精神卫生中心药剂科,西安 710061
- 2. 西安市精神卫生中心人事科,西安 710061
- 折叠
摘要
Abstract
OBJECTIVE:To investigate off-indication use of oral chemical drugs medical orders by the standards of CFDA and FDA,and to compare the differences between the two standards,analyze reasons and rationality of drug use,so as to pro-vide reference for establishing off-indications use management system. METHODS:The oral chemical drugs medical orders of inpatients were analyzed statistically during Jan.-Jun. 2016. Off-label uses was judged according to the standards of CFDA and FDA. RESULTS:Totally 507 oral chemical drugs medical orders were collected,the percentage of off-indications use were in high level,being 58.58% and 55.82% respectively by the standards of CFDA and FDA. The incidence of off-indication use of quetiapine and aripiprazole by the CFDA standards were significantly higher than the results of FDA standards,with statistical significance(P<0.05). Magnesium valproate(54.03%),escitalopram oxalate(10.45%)and quetiapine(10.15%)occupied the top 3 places in the list of constituent ratio. Among off-indication medical orders,7 orders had no evidence-based medicine,ac-counting for 2.36% of total. CONCLUSIONS:Most off-indication medical orders of our hospital could provide the basis and lit-erature support,while there are still a few off-indication use with insufficient evidence. The corresponding management system of the hospital should be formulated to guarantee the medication safety of the patients and legitimate rights and interests of the doctors.关键词
精神专科药物/超适应证用药/医嘱/合理用药Key words
Psychiatric drugs/Off-indication use/Medical order/Rational drug use分类
医药卫生引用本文复制引用
贾晓妮,权伟,陈建波,岳丹萍,支媗,张晓红..CFDA和FDA标准下我院精神专科药物超适应证使用比较分析[J].中国药房,2017,28(14):1899-1903,5.
