中国药房2017，Vol.28Issue(14)：1934-1937,4.DOI:10.6039/j.issn.1001-0408.2017.14.17
肾福康胶囊治疗肾功能不全的临床研究
Clinical Study on Shenfukang Capsules for Renal Insufficiency
摘要
Abstract
OBJECTIVE:To investigate the effects of Shenfukang capsules on clinical efficacy and renal function indexes of patients with renal insufficiency. METHODS:Totally 100 inpatients with renal insufficiency treated by Shenfukang cap-sules in the First Affiliated Hospital of Guangxi Medical University during Feb. to Mar. 2015 were analyzed retrospectively in respects of general information of patients,therapy plan,renal function indexs before and after treatment and clinical effica-cy. The relationship of clinical efficacy with age and duration was also analyzed. RESULTS:There were 33 cases of acute re-nal insufficiency and 67 cases of chronic renal insufficiency. The route of administration of Shenfukang capsules was oral ad-ministration(97 cases,97.00%),the main dosage was 6 capsule/d(36 cases,36.00%),and treatment duration were 0-<7 days(39 cases)and 7-<15 days(49 cases). After treatment,the average serum creatinine concentration was lower than be-fore treatment,while mean GFR and Ccr were higher than before treatment,with statistical significance(P<0.05). The total response rate was 72.00%,and response rate of patients with acute renal insufficiency was 87.88% and significantly higher than 64.18% of patients with chronic renal insufficiency,with statistical significance(P<0.05). Among patients with ≤60 years old,the total response rate of patients with acute renal insufficiency was significantly higher than that of patients with chronic renal insufficiency,with statistical significance(P<0.05);among patients elder than 60 years old,there was no statistical significance in therapeutic efficacy between acute renal insufficiency and chronic renal insufficiency(P>0.05);among patients with chronic renal insufficiency,the total response rate of patients elder than 60 years old was significantly better than that of patients with ≤60 years old,with statistical significance (P<0.05). With the extension of treatment duration,the total response rate of patients with acute renal insufficiency was on the rise,and that of patients with chron-ic renal insufficiency increased first and then decreased. No obvious ADR was found during treatment. CONCLUSIONS:Shenfu-kang capsules can improve renal function in patients with renal insufficiency,and has definite curative effect on acute and chronic renal insufficiency with good security. The clinical efficacy may be related to age and treatment course.关键词
肾福康胶囊/肾功能不全/疗效分析/合理用药Key words
Shenfukang capsules/Renal insufficiency/Therapeutic efficacy analysis/Rational use of drug分类
医药卫生引用本文复制引用
蔡果珍,钟小斌,杨玉芳,邹小琴,农秋萍,陆斯斯,梁雪艳..肾福康胶囊治疗肾功能不全的临床研究[J].中国药房,2017,28(14):1934-1937,4.基金项目
国家自然科学基金资助项目(No.81260598、81560729) （No.81260598、81560729）
广西医疗卫生适宜技术研究与开发基金资助项目(No.S201302-03) （No.S201302-03）
广西壮族自治区中医药民族医药自筹课题(No. gzzc1233) （No. gzzc1233）
