中国药理学与毒理学杂志2017，Vol.31Issue(5)：375-384,10.DOI:10.3867/j.issn.1000-3002.2017.05.001
苯并(a)芘致癌的表观遗传学作用机制研究进展
Research progress in cancer epigenetics mechanisms of benzo (a) pyrene
摘要
Abstract
In recent years, researches on cells, animals, and human beings have found that the carcinogenic mechanism of environmental carcinogen benzo (a) pyrene〔B(a)P〕can reduce methyla?tion of the whole genes, increase the tumor suppressor gene methylation and reduce the gene methyla?tion of proto-oncogene, in addition to the genetic toxicity. It can also cause changes in small RNA expression, the increase of long-chain non-coded RNA expression and imbalance in histone phosphor?ylation expressions. These changes can cause abnormalities in gene expression and chromosome structure and instability, directly leading to cancer. These changes can also cause the corresponding changes of genetic toxicity, such as gene mutation, abnormal genetic damage repair, increas of cell apoptosis and cell cycle arrest. All these are considered to be potential epigenetic mechanisms of B(a)P. Existing researches have provided the scientific basis for the mechanism of and prevention counter?measures for environment-related diseases and vocational diseases caused by B(a)P.关键词
苯并(a)芘/表观遗传学/DNA甲基化/微RNA/长链非编码RNA/组蛋白修饰Key words
benzo (a) pyrene/epigenetics/DNA methylation/microRNA/long ioncocling RNA/histone modification分类
医药卫生引用本文复制引用
周超文,胡建安..苯并(a)芘致癌的表观遗传学作用机制研究进展[J].中国药理学与毒理学杂志,2017,31(5):375-384,10.基金项目
国家自然科学基金(81372966)The project supported by National Natural Science Foundation of China (81372966) （81372966）
