中国肿瘤生物治疗杂志2017，Vol.24Issue(4)：335-340,6.DOI:10.3872/j.issn.1007-385X.2017.04.001
PD-L1表达调控机制及其对抗肿瘤免疫反应的影响
Regulation mechanism of PD-L1 expression and its effect on antitumor immune responses
摘要
Abstract
Tumorigenesis is a complex process involving multistep.Tumor cells escape from immune of the host and promote their proliferation via inhibiting antitumor immune responses of the host.Molecular mechanism of the tumor immune escape is one of core issues about the tumor immune research.Programmed death receptor-1 (PD-1) is a key checkpoint for the inhibit immunity.The tumors can enhance inhibit signal of PD-1 and promote their immune escape through expression of programmed death ligand-1 (PD-L1).Research on how tumor cells regulate expression of PD-L1 can help to expound molecular mechanism of the tumor immune escape.Recently,some researches found tumor cells regulate expression of PD-L1 on multisteps of gene translation,post-transcriptional regulation and post-translational modification of proteins,as well as affect the anti-tumor immune responses through regulating expression of PD-L1.The researches provided novel targets for the immunotherapy of tumors.关键词
肿瘤/肿瘤免疫/程序性死亡受体-1/程序性死亡配体-1/免疫逃逸/免疫调节/生物治疗Key words
tumor/tumor immunology/programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1)/immune escape/immune regulation/biotherapy分类
医药卫生引用本文复制引用
朱凌曦,安华章..PD-L1表达调控机制及其对抗肿瘤免疫反应的影响[J].中国肿瘤生物治疗杂志,2017,24(4):335-340,6.基金项目
国家重点研发计划课题(No.2016YFA0502201).Project supported by the National Key Research and Development Program of China (No.2016YFA0502201) （No.2016YFA0502201）
