中国肿瘤生物治疗杂志2017，Vol.24Issue(4)：362-366,5.DOI:10.3872/j.issn.1007-385X.2017.04.005
循环肿瘤细胞联合血清胃泌素释放前肽及神经元特异性烯醇化酶水平对SCLC化疗疗效的评估意义
Significance of circulating tumor cells combined with gastrin releasing peptide and neuron specific enolase levels in evaluating the efficacy of chemotherapy for patients with small cell lung cancer
摘要
Abstract
Objective:To explore the significance of peripheral blood circulating tumor cells (CTCs) combined with gastrin releasing peptide (pro-GRP) and neuron specific enolase (NSE) in evaluating the chemotherapy efficacy for small cell lung cancer (SCLC) patients.Methods:Forty SCLC patients treated in the department of respiratory and critical care of Changhai Hospital from October 1,2015 to November 30,2016 were included in this study.The peripheral blood was extracted from patients before the chemotherapy of first and third cycle to determine the level of CTCs,pro-GRP and NSE,and to analyze their relationship to the efficacy of chemotherapy.Meanwhile,all patients underwent the chest CT before the first and the third cycle of chemotherapy,to compare the differences between CTCs combined with pro-GRP,NSE evaluation and RECIST standard in judging the efficacy of chemotherapy.In addition,the correlation between CTCs number and clinical characteristics of patients were also analyzed.Results:In 40 SCLC patients,the CTCs positive rates detected at two times were 82.5％,87.5％,respectively.The more CTCs number decreased after chemotherapy,the better effect of chemotherapy was.According to RECIST criteria,there was significant difference in the change of CTCs number between tumor progression group and tumor control group (P ＜ 0.05).According to CTCs number evaluation criteria,tumor control was not significantly correlated with age,sex,smoking,tumor size and tumor stage (P ＜ 0.05).There was a consistency in evaluating the efficacy of chemotherapy between CTCs number evaluation criteria and RECIST criteria (P ＞ 0.05).Combined detection of CTCs,pro-GRP and NSE in evaluating the chemotherapy efficacy has the same result as RECIST evaluation (P ＞ 0.05),and the joint detection can improve the sensitivity of efficacy judgment.Conclusion:There was a negative correlation between the change of CTCs number and the efficacy of chemotherapy.Combing detection of CTCs,pro-GRP and NSE to evaluate the efficacy of chemotherapy for SCLC patients has a higher sensitivity.关键词
小细胞肺癌/循环肿瘤细胞/胃泌素释放前肽/神经元特异性烯醇化酶/化疗疗效Key words
small cell lung cancer (SCLC)/circulating tumor cells (CTCs)/gastrin releasing peptide (pro-GRP)/neuron specific enolase (NSE)/chemotherapy efficacy分类
医药卫生引用本文复制引用
苗欣,赵家义,范银星,李佳浓,韩一平..循环肿瘤细胞联合血清胃泌素释放前肽及神经元特异性烯醇化酶水平对SCLC化疗疗效的评估意义[J].中国肿瘤生物治疗杂志,2017,24(4):362-366,5.基金项目
国家卫生部科技发展研究基金资助(No.W2012F2043).Project supported by the Science and Technology Development Program from Ministry of Health of China (No.W2012F2043) （No.W2012F2043）
