中国中医药信息杂志2017，Vol.24Issue(6)：22-26,5.DOI:10.3969/j.issn.1005-5304.2017.06.006
益气固表丸联合平喘敷贴膏治疗慢性阻塞性肺疾病稳定期临床研究
Clinical Study on Yiqi Gubiao Pill Combined with Pingchuan External Application Ointment for Treatment of Patients with Chronic Obstructive Pulmonary Disease at Stable Stage
摘要
Abstract
Objective To observe efficacy and safety of Yiqi Gubiao Pill combined with Pingchuan External Application Ointment for the treatment of COPD (lung-spleen qi deficiency type) at a stable stage. Methods A randomized, double-blind, and placebo-controlled method was used. Totally 266 cases of patients diagnosed with COPD lung-spleen qi deficiency syndrome were randomly divided into four groups. Experimental Ⅰ group (72 cases) was given Yiqi Gubiao Pill, 10 pills each time, three times a day, orally; at the same time, experimental Ⅰ group was given simulated Pingchuan External Application Ointment (blank medical bag), for Feishu (BL13), danzhong (RN17), Pishu (BL20), Fengmen (BL12), and Dingchuan, external application at 11am each day, external heating stickers, 4-6 h each time, twice a week. Experimental Ⅱ group (64 cases) was given simulated Yiqi Gubiao Pill combined with Pingchuan External Application Ointment. Experimental (64 cases) was givenⅢ Yiqi Gubiao Pill combined with Pingchuan External Application Ointment. Control group (66 cases) was given simulated Yiqi Gubiao Pill combined with simulated Pingchuan External Application Ointment. The treatment lasted for three months, and the follow-up was three months. TCM symptom scores, FEV1%, FVC%, CAT, BODE index, mMRC, and 6MWT were observed. Results After three-month treatment and three-month follow-up, the improvement of TCM symptom scores of the 3 experimental groups was better than the control group (P<0.05). The improvement of CAT, mMRC, BODE index, 6MWT, mMRC in the three treatment groups were better than the control group (P<0.05). The improvement of mMRC and BODE in experimental Ⅰ and Ⅱ groups were better than those of experimental group (Ⅲ P<0.05). After three-month treatment, the improvement of FVC% in the three experimental groups was better than the control group (P<0.05). The improvement of FEV1% in the experimental Ⅱ and groups was better than the control groupⅢ(P<0.05). Conclusion Yiqi Gubiao Pill combined with Pingchuan External Application Ointment has obvious efficacy for the treatment of COPD with lung-spleen qi deficiency type.关键词
益气固表丸/平喘敷贴膏/慢性阻塞性肺疾病/稳定期Key words
Yiqi Gubiao Pill/Pingchuan External Application Ointment/chronic obstructive pulmonary disease/stable stage分类
医药卫生引用本文复制引用
李风森,徐丹,高振,李争,荆晶,张艳丽,王晶..益气固表丸联合平喘敷贴膏治疗慢性阻塞性肺疾病稳定期临床研究[J].中国中医药信息杂志,2017,24(6):22-26,5.基金项目
新疆维吾尔自治区科技创新团队培养建设项目(2014751005) （2014751005）
