中国中医药信息杂志2017，Vol.24Issue(6)：91-96,6.DOI:10.3969/j.issn.1005-5304.2017.06.023
基于数据挖掘的植物类中药寒热药性-功效-靶点关联性研究
Correlation Study on "Cold or Heat Property-Efficacy-Target" of Herbal Chinese Materia Medica Based on Data Mining
摘要
Abstract
Objective To study the correlation among property, efficacy and target of herbal Chinese materia medica; To analyze the molecular mechanism of cold and heat property of Chinese materia medica; To provide references for explaination of microcosmic mechanism and scientific connotation of property of Chinese materia medica. Methods Recordings about property and efficacy of single medicine in 2015 edition of Pharmacopoeia of the People's Republic of China were sorted out. According to Pharmacological Research of New Ideas and New Targets and Pharmacology, 509 kinds of herbal Chinese materia medica were selected. Relevant articles about property, efficacy, pharmacologic action, and target in CNKI and Chinese Academic Journal Database (Wanfang Data) were searched by computers. The target information was screened and standardized, and the database was constructed by using MySQL5.7.13. The correlation between the property, efficacy and the target of the herbal Chinese materia medica was studied by using the frequency analysis and correlation rule algorithm of R software platform 3.3.1. Results 509 kinds of herbal Chinese materia medica were selected, including 227 kinds of cold-property medicine, 106 kinds of neutural-property medicine and 176 kinds of hot-property medicine. According to the result of data mining, efficacy of cold-roperty medicine was quenching thirst, clearing liver and treating stranguriaetc. The target was transforming growth factor β2 and liver microsome, etc. The efficacy of hot-property medicine was warming the middle, releasing cold and dissolving lumps. The target was bone morphology protein 2, rheumatoid factor, etc. The efficacy of neutural-property medicine was clearing lungs, diminishing distension and increasing energy. The target was β-amyloid and prostaglandin E2 receptors. Conclusion There is certain correlation in property, efficacy and target in Chinese materia medica.关键词
植物类中药/药性/功效/靶点/关联性/数据挖掘Key words
herbal Chinese materia medica/property/efficacy/target/correlation/data mining分类
医药卫生引用本文复制引用
肖雨函,王乃智,张静雯,曹金花,王凤祥,崔双玮,付先军..基于数据挖掘的植物类中药寒热药性-功效-靶点关联性研究[J].中国中医药信息杂志,2017,24(6):91-96,6.基金项目
国家自然科学基金(81473369) （81473369）
教育部高等学校博士学科点专项科研基金(20123731120001) （20123731120001）
山东省人力资源和社会保障厅博士后创新项目(201102036) （201102036）
山东中医药大学大学生研究训练计划(201310441107) （201310441107）
