癌变·畸变·突变2017，Vol.29Issue(3)：222-225,234,5.DOI:10.3969/j.issn.1004-616x.2017.03.012
外周血白细胞端粒相对长度与噪声性听力损失的相关性研究
Correlation between telomere length of peripheral blood leukocytes and noise-induced hearing loss
摘要
Abstract
OBJECTIVE: To study the correlation between telomere length of peripheral blood leukocytes and noise-induced hearing loss. METHODS:In a factory that produced computer shells,all posts that had noise intensity LEX,8 h≥85 dB(A),as determined by SV104IS wireless noise intensity detector,were selected. Questionnaires were used for collecting general and occupational information from workers and real-time polymerase chain reaction was used to detect telomere length of their peripheral blood leukocytes. Ordinal ploytomous logistic regression was used for analyzing the correlation between telomere length and noise-induced hearing loss. RESULTS:The average noise intensity among LEX,8 h of overproof posts in the factory was (91.30±3.22) dB(A). This study recruited 127 noise-exposed workers consisting of 43 normal hearing workers (33.86%),75 abnormal high-frequency hearing loss workers (59.06%),9 abnormal speech-frequency hearing loss accompanied with abnormal high-frequency hearing loss (7.09%). Statistical significance was found in relative telomere length between different levels of noise-induced hearing loss (P<0.05). It was revealed that noise intensity,age,gender and relative telomere length were factors related to noise-induced hearing loss (P<0.05). CONCLUSION:Relative telomere length of peripheral blood leukocytes can potentially be used as a biomarker of susceptibility for noise-induced hearing loss.关键词
外周血白细胞/端粒/相对长度/噪声性听力损失Key words
peripheral blood leukocyte/telomere/relative length/noise-induced hearing loss分类
医药卫生引用本文复制引用
刘新霞,陆垚,刘浩中,何云..外周血白细胞端粒相对长度与噪声性听力损失的相关性研究[J].癌变·畸变·突变,2017,29(3):222-225,234,5.基金项目
国家自然科学基金(81273097,81472998) （81273097,81472998）
中山市科技计划项目医疗卫生重大科技专项(2015B1009) （2015B1009）
