癌变·畸变·突变2017，Vol.29Issue(3)：226-229,4.DOI:10.3969/j.issn.1004-616x.2017.03.013
粤东地区妇女
人乳头瘤病毒感染
情况和亚型分布
及其与宫颈癌的关系
Prevalence of human papilloma-virus genotypes and associated risk of cervical carcinoma in Chaoshan population
沈伶 1许丽璇 1李小平 1胡桂英 2麦碧 2纪璇 3粟丽1
作者信息
- 1. 汕头大学医学院第一附属医院妇产科,广东 汕头 515031
- 2. 广东省妇幼保健院妇科,广东 广州 510010
- 3. 汕头大学医学院第一附属医院中医科,广东 汕头 515031
- 折叠
摘要
Abstract
OBJECTIVE: To determine genotype-specific distribution of human papillomavirus (HPV) in women and to identify its relationship with cervical carcinoma in Chaoshan population. METHODS:Data from 30000 women who were subjected to cervical HPV DNA testing were retrospectively evaluated in a hospital-based study. A total of 8739 women,who had both HPV typing and pathological examination,were investigated. RESULTS:Overall,30.00%(9000/30000) of women were HPV positive,the frequency of HPV infection was 58.29% (5094/8739) in women with cervical cytological abnormalities,and the infection rate for patients with chronic cervicitis was 40.00% (1088/2720),patients with CIN I was 53.59%(1396/2605),patients with CIN was Ⅱ/Ⅲ 71.61% (1647/2300) and patients with cervical carcinoma was 86.45%(963/1114). HPV 16 (14.02%) was the most common type for all cervical cytological abnormalities,followed by 18 type 6.28%(549),33 type 5.23%(457),58 type 4.46%(390) and 52 type 3.71%(324),while the more common HPV 16 type in cervical carcinoma with the highest infection (49.92%) was in women aged over 60. CONCLUSION:Our data indicate a relatively high prevalence of HPV 16,52,33,58 and 18 in women,their positive association with cervical cytological abnormalities. Specifically,the HPV 16 was the most common subtype among senior women with cervical carcinoma.关键词
粤东地区/人乳头瘤病毒/亚型分布/宫颈癌Key words
Chaoshan area/human papillomavirus/genotype/cervical carcinoma分类
医药卫生引用本文复制引用
沈伶,许丽璇,李小平,胡桂英,麦碧,纪璇,粟丽..粤东地区妇女
人乳头瘤病毒感染
情况和亚型分布
及其与宫颈癌的关系[J].癌变·畸变·突变,2017,29(3):226-229,4.
