癌变·畸变·突变2017，Vol.29Issue(3)：230-234,5.DOI:10.3969/j.issn.1004-616x.2017.03.014
胃癌患者血浆某些 化学元素含量的病例对照研究
A case control study on presence of chemical elements in plasma of gastric cancer patients
摘要
Abstract
OBJECTIVE: To compare the presence of chemical elements in plasma between gastric cancer patients and healthy people. METHODS:Using a case-control design,we focused on people who had lived in Xianyou for 10 years or more. Among them,we identified newly discovered cases of pathologically confirmed gastric cancer (299 cases) and 295 health cases. Among these cases,we obtained general situation information,living habits,etc. using questionnaires and collected blood samples. Blood samples were subjected to microwave digestion and chemical elements in plasma were analyzed by inductively coupled plasma mass spectrometry. The presence of chemical elements between the two groups were compared using non-parametric tests. RESULTS:Cu,Mg,and Cu/Zn in the case group were significantly higher than that in the control (P<0.01). However,Mo,Ca in the case group were significantly lower (P<0.01). Multivariate analysis showed that Cu (OR=2.71),Mg (OR=2.26),Cu/Zn (OR=3.88) were significantly associated with increased risk for gastric cancer but Mo (OR=0.48),Ca (OR=0.17) with significantly reduced risk. CONCLUSION:Levels of some plasma chemical elements in gastric cancer patients were significantly different from that of the normal population.关键词
化学元素/胃癌/病例对照/血浆Key words
chemical element/gastric cancer/case control/plasma分类
医药卫生引用本文复制引用
刘福志,李宏图,吴传城,蔡爱兰,陈昱,刘宝英..胃癌患者血浆某些 化学元素含量的病例对照研究[J].癌变·畸变·突变,2017,29(3):230-234,5.基金项目
福建省仙游县消化道肿瘤病因学、流行病学研究项目(2013B008) （2013B008）
福建省自然科学基金(2015J01673,2017J01811) （2015J01673,2017J01811）
