吉林大学学报（医学版）2017，Vol.43Issue(3)：607-610,4.DOI:10.13481/j.1671-587x.20170327
头孢哌酮钠舒巴坦钠对反复下呼吸道感染患者中性粒细胞胞外网状陷阱形成的影响
Effect of sulbactam sodium/cefoperazone sodium on neutrophil extracellular traps of patients with recurrent lower respiratory tract infection
摘要
Abstract
Objective:To detect the neutrophil extracellular traps (NETs) formation in the peripheral blood of the patients with recurrent respiratory tract infection,and to evaluate the effect of sulbactam sodium/cefoperazone sodium on the formation of NETs.Methods:A total of 36 patients with recurrent respiratory tract infection (case group) and 30 healthy volunteers (healthy control group) were selected.The NETs formation of subjects in two groups was detected by confocal microscope and scanning electron microscope (SEM).According to the appearance of neutrophils,the formation of NETs was classified as grade Ⅰ,Ⅱ and Ⅲ,the number of NETs formation cells of subjects in two groups was calculated.The formation of NETs of the patients in case group were detected before and after treated with sulbactam sodium/cefoperazone sodium.Results:The number of NETs formation cells of grade Ⅰ and Ⅱ of the patients in case group was more than that in healthy control group (P<0.05);while the number of NETs formation cells of grade Ⅲ of the patients in case group was less than that in healthy control group (P<0.05).The number of NETs formation cells of grade Ⅰ and Ⅱ of the patients in case group were significantly decreased (P<0.05),while the number of NETs formation cells of grade Ⅲ was significantly increased (P<0.05) after treated with sulbactam sodium/cefoperazone sodium.Conclusion:A lot of NETs with high antibacterial function can be formed in the patients with recurrent lower respiratory tract infection,and sulbactam sodium/cefoperazone sodium can inhibit the formation of NETs.关键词
反复下呼吸道感染/中性粒细胞胞外网状陷阱/头孢哌酮钠舒巴坦钠/激光共聚焦显微镜/扫描电镜Key words
recurrent lower respiratory tract infection/neutrophil extracellular traps/sulbactam sodium/cefoperazone sodium/confocal microscope/scanning electron microscope分类
医药卫生引用本文复制引用
唐颖,黄元平,荆文花,关英慧..头孢哌酮钠舒巴坦钠对反复下呼吸道感染患者中性粒细胞胞外网状陷阱形成的影响[J].吉林大学学报（医学版）,2017,43(3):607-610,4.基金项目
吉林省科技厅科技发展计划项目资助课题(20110489) （20110489）
吉林大学第一医院二部科研专项基金资助课题(B-24) （B-24）
