川北医学院学报2017，Vol.32Issue(2)：160-162,196,4.DOI:10.3969/j.issn.1005-3697.2017.02.002
吉西他滨与顺铂联合化疗对晚期非小细胞肺癌患者CYFRA21-1、IGF-1及VEGF的影响
The effects of combined chemotherapy with gemcitabine and cisplatin on CYFRA21-1,IGF-1 and VEGF in patients with advanced non-small cell lung cancer
摘要
Abstract
Objective:To investigate the effects of combined chemotherapy with gemcitabine and cisplatin on CYFRA21-1,insulin-like growth factors-1 (IGF-1) and vascular endothelial growth factor (VEGF) in patients with advanced non-small cell lung cancer(NSCLC).Methods: 78 cases of patients with advanced NSCLC in our hospital from January 2015 to December 2016 were selected as clinical data,the observation group have 78 cases who were treated with combined chemotherapy with gemcitabine and cisplatin,and 82 healthy people were selected as the control group.Results: The levels of CYFRA21-1 and IGF-1 in the observation group were significantly lower than those before treatment,and the levels of serum CYFRA21-1 and IGF-1 were significantly higher than those in the control group.The level of VEGF in the observation group was higher than that before treatment,and the serum VEGF level was higher than that in the control group,the difference was statistically significant (P<0.05).After treatment,the total remission rate of the observation group was 29.49% (23/78),the levels of CYFRA21-1,IGF-1 and VEGF in the PR group were significantly lower than those in the SD+PD group.The levels of CYFRA21-1 and IGF-1 in the PR group were significantly lower than those before treatment,the serum VEGF level of patients in group PR was higher than that before treatment,the serum VEGF level in patients with SD+PD group was higher than that before treatment,the difference was statistically significant (P<0.05).Conclusion: The combined chemotherapy with gemcitabine and cisplatin can decrease the expression of CYFRA21-1 and IGF-1 and increase the level of VEGF in patients with advanced NSCLC,it has clinical value in the evaluation of chemotherapy efficacy.关键词
非小细胞肺癌/吉西他滨/顺铂/胰岛素样生长因子-1/血管内皮生长因子Key words
Non-small cell lung cancer/Gemcitabine/Cisplatin/IGF-1/VEGF分类
医药卫生引用本文复制引用
张栓宝,姚俊涛..吉西他滨与顺铂联合化疗对晚期非小细胞肺癌患者CYFRA21-1、IGF-1及VEGF的影响[J].川北医学院学报,2017,32(2):160-162,196,4.基金项目
国家自然科学基金(30801385) （30801385）
