川北医学院学报2017，Vol.32Issue(2)：197-201,5.DOI:10.3969/j.issn.1005-3697.2017.02.013
齐拉西酮与利培酮治疗首发精神分裂症疗效与安全性的系统评价
Systematic review of the efficacy and safety of Ziprasidone and Risperidone in the treatment of first episode schizophrenia
摘要
Abstract
Objective:To systematically review the efficacy and safety of Ziprasidone versus Risperidone in the treatment of first-episode schizophrenia,and provide evidence-based reference for clinical treatment.Methods:Searched the clinical control study of the Ziprasidone and Risperidone in the treatment of first-episode schizophrenia by pubmed,EMbase,EBSCO,CBM,CNKI,VIP and WanFang data bank.After quality evaluation and data extract,meta-analysis was performed by using Rev Man 5.0 statistics software.Results: A total of 29 RCT were included,involving 2 424 patients.Results of meta-analysis showed that the efficacy rate and the total efficiency rate of Ziprasidone and Risperidone had no significant difference(P>0.05);In the adverse drug reactions,the incidences of extrapyramidal reactions[P=0.000 7,OR=0.37,95%CI=(0.21,0.66)],the incidences of weight gain[P<0.001,OR=0.19,95%CI=(0.13,0.29)] and the incidences of prolactin increasing[P<0.001,OR=0.08,95%CI=(0.05,0.14)] of control group were significantly more than test group with statistically significant difference;the incidences of headache[P=0.02,OR=1.85,95%CI=(1.11,3.11)] and the incidences of electrocardiographic abnormality[P=0.002,OR=2.59,95%CI=(1.44,4.65)] were significantly lower than test group with statistically significant difference.Conclusion: The efficacy of the Ziprasidone and Risperidone in the treatment of first episode schizophrenia is similar,the incidences of extrapyramidal reaction metabolic disorders less risperidone,and the incidences of headache and abnormal electrocardiogram more than risperidone.Because of limited method logical quality and sample size,it remains to be further verified with more rigorously designed and long-term follow-up of large-scale RCT.关键词
齐拉西酮/利培酮/首发精神分裂症/系统评价/Meta分析Key words
Ziprasidone/Risperidone/First episode schizophrenia/Systematic review/Meta-analysis引用本文复制引用
范小冬,谢星星,张杰,张春燕,孔文强,杜彪..齐拉西酮与利培酮治疗首发精神分裂症疗效与安全性的系统评价[J].川北医学院学报,2017,32(2):197-201,5.基金项目
重庆市社会事业与民生保障科技创新专项(cstc2015shmszx120073) （cstc2015shmszx120073）
重庆市万州区科技计划基金资助项目(201403055) （201403055）
