王莉莉 1和健伟 1黄刚 1杜斌斌 1赵雪梅 1张文文 1周星 1马娅琼1
作者信息
- 1. 甘肃省人民医院放射科,兰州 730000
- 折叠
摘要
Abstract
Objective: To evaluate the potential association between DKI parameters and D2-40, CD31, S-100 and Ki-67 with immunohistochemical analysis of rectal cancer. Materials and Methods: Data from 69 patients who were confirmed by surgical pathology from January to September in 2016. All cases were performed by regular sequence and DKI and DTI (diffusion tensor imaging) examination. The following parameters were acquired from the entire tumors. Respectively as Dax, Dmean, Drad, Fa, Kax, Kmean, Krad. D2-40, CD31, S-100 and Ki-67 were detected by Ben CHMARK-XT machine and Mul-timer system. D2-40 and CD31 were divided into two groups according to the expression of positive or negative and independent-sample t test was used for statistical analysis. Receiver operating characteristic curves and Pearson correlation were used for statistical analysis. Results: The levels of MK, K⊥ value in D2-40, CD31 positive group were significant higher than negative group. The differences were statistically significant (P<0.05). Whereas MD in D2-40, CD31, positive group were significantly lower than negative group, the differences were statistically significant (P<0.05). Pearson correlation analysis showed Ki-67 was significant positive correlation with MK, K⊥, K// parameters, whereas Ki-67 showed negative correlation with D⊥, D//, MD. ROC curve was applied to analysis of DKI parameters in D2-40, CD31 positive group and negative group. Conclusions: MK can reflect the tissue microenvironment including its component organelles, cell membranes, and water compartments, maybe preoperative noninvasive assessment of D2-40, CD31, S-100 and Ki-67 expression level, indirectly reflect the degree of tumor cell proliferation, provide a reference for colorectal malignant degree and prognosis of preoperative evaluation basis.关键词
弥散峰度成像/平均峰度/免疫组织化学/Ki-67抗原Key words
Diffusion-kurtosis image/Mean kurtosis/Immunohistochemistry/Ki-67 antigen分类
医药卫生
