重庆医学2017，Vol.46Issue(14)：1885-1888,4.DOI:10.3969/j.issn.1671-8348.2017.14.005
香烟烟雾染毒对雄性大鼠睾丸组织一氧化氮水平的影响
The effect of cigarette smoke exposure on nitric oxide level in testis of male rats
摘要
Abstract
Objective To explore the effect of cigarette smoke exposure on testis structure and nitric oxide (NO) level in testis of rats.Methods A total of 160 adult male SD rats were divided into control group and low,medium,high dose groups.The smoke-exposed rats were respectively exposed to the smog for the periods of 2,4,6,8 and 12 weeks,10 rats in each group.The smoke-exposed rats were exposed to cigarette smoke for 0.5 h per day.The testicular tissue structure was observed and the body mass and the NO level of testis were measured.Results Compared with the control group and low dose group,the body mass of the rats was significantly lower in the medium and high dose groups exposed for 4,6,8,12 weeks (P<0.05).Compared with the medium dose groups,the body mass of the rats was significantly lower in the high dose group exposed for 8 weeks and 12 weeks (P<0.05).And with the increase of exposure dose,the reducing was even more obvious.Compared with the control group and low and medium dose groups,NO level in testis of rats was significantly increased in the high dose groups exposed for 2,4,6,8 weeks (P<0.05).Compared with the control group,NO level in testis of rats was significantly increased in the medium dose groups exposed for 8 weeks (P<0.05).Compared with the control group,NO level in testis of rats was significantly increased in the low,medium and high dose groups exposed for 12 weeks (P<0.05);and compared with the low dose group,NO level in testis of rats was significantly increased in the medium and high dose groups(P<0.05).Conclusion Cigarette smoke exposure may have impacts on testis tissue and lead to the increase of NO level in testis of male rats.关键词
睾丸/烟草/烟雾/毒物/雄性大鼠/一氧化氮Key words
testis/tobacco/smog/poisons/male rats/nitric oxide分类
医药卫生引用本文复制引用
张静,邓晟,仲春雪,黄云飞,张晨,何丽娟,邹莹..香烟烟雾染毒对雄性大鼠睾丸组织一氧化氮水平的影响[J].重庆医学,2017,46(14):1885-1888,4.基金项目
国家自然科学基金资助项目(81260433) （81260433）
新疆维吾尔自治区自然科学基金项目(2014211C015). （2014211C015）
