重庆医学2017，Vol.46Issue(14)：1907-1909,3.DOI:10.3969/j.issn.1671-8348.2017.14.011
丁苯酞对脑梗死认知障碍患者记忆运动及事件相关电位的影响
The influence of butylphthalide on the memory,movement and ERP in patients with cerebral infarction cognitive impairment
摘要
Abstract
Objective To investigate the effect of butylphthalide on the memory,movement and ERP (event-related potentials) in patients with cerebral infarction cognitive impairment.Methods A total of 134 patients with cerebral infarction cognitive impairment were randomly divided into treatment group (67 patients) and control group (67 patients).All patients were given conventional cerebral infarction treatment as well as cognitive improvement intervention.Oral administration of butylphthalide was added onto the patients in the treatment group.Curative effects were observed after 30 days′ continued treatment.The cognitive function scores,memory scores,movement scores,ERP test and adverse reaction were compared between the two groups before and after treatment.Results After 30 days′ treatment,two groups of the montreal cognitive assessment scale (MoCA) scores were 27.2±4.9 and 25.1±4.1 respectively;the total scores of memory were 5.5±0.5 and 4.9±0.5 respectively;the scores of motor assessment scale (Fugl-meyer) were 85.6±6.2 and 74.2±6.1 respectively and P3 amplitudes were (9.5±0.9)μV and (8.1±0.9)μV respectively.All the indexes mentioned above in treatment group were significantly increased compared with those of before treatment(P<0.05).The results of N1,N2,P2 and P3 in the latency detection were significantly decreased compared with those of before treatment(P<0.05).And the results of P2 and P3 in the latency detection of the treatment group were shorter than those of the control group(P<0.05).After treatment,no adverse reaction was observed in both groups.Conclusion Based on conventional cerebral infraction treatment,oral administration of butyraldehyde effectively improve the therapeutic effect.关键词
苯丙酮类/丁苯酞/脑梗死/认知障碍/事件相关电位Key words
propiophenones/butylphthalidel/cerebral infarction/cognitive impairment/ERP分类
医药卫生引用本文复制引用
靳玫,马世江,沈长波,王文晟..丁苯酞对脑梗死认知障碍患者记忆运动及事件相关电位的影响[J].重庆医学,2017,46(14):1907-1909,3.基金项目
河南省自然科学基金资助项目(162300410217) （162300410217）
国家自然科学基金面上项目(31170733). （31170733）
