重庆医学2017，Vol.46Issue(14)：1912-1914,3.DOI:10.3969/j.issn.1671-8348.2017.14.013
ABCG2和ALDH1在卵巢子宫内膜异位症恶变中的表达和影响研究
Expression and significance of ABCG2 and ALDH1 in malignant transformation of ovarian endometriosis
摘要
Abstract
Objective To investigate the expression and significance of ABCG2 and ALDH1 in malignant transformation of ovarian endometriosis.Methods The protein expressions of ABCG2 and ALDH1 were detected with immunohistochemistry in 38 cases of malignant transformation of ovarian endometriosis(EMs malignant transformation group),35 cases of endometriosis(EMs group)and 30 cases of normal endometrium(control group).Results The positive rates of ABCG2 and ALDH1 expressions in EMs malignant transformation group were significantly higher than those in EMs group and control group(P<0.05).The expressions of ABCG2 and ALDH1 were significantly associated with the serum CA125 level,differentiation and clinical stage of malignant transformation of ovarian endometriosis (P<0.05),but were not related to the patient′s age,dysmenorrhea history and pathology type(P>0.05).There was no correlation between the expression of ABCG2 and ALDH1 in malignant transformation of ovarian endometriosis(P>0.05).Conclusion The expressions of ABCG2 and ALDH1 might be involved in malignant transformation of ovarian endometriosis.关键词
卵巢囊肿/子宫内膜异位症/变态反应和免疫学/干细胞/三磷酸腺苷结合盒超家族G家族成员2/乙醛脱氢酶1Key words
ovarian cysts/endometriosis/allergy and immunology/stem cells/ABCG2/ALDH1分类
医药卫生引用本文复制引用
刘颂平,田鑫,温坚,殷新明..ABCG2和ALDH1在卵巢子宫内膜异位症恶变中的表达和影响研究[J].重庆医学,2017,46(14):1912-1914,3.基金项目
江苏省自然科学基金资助项目(BK20140502) （BK20140502）
江苏省"六大人才高峰"资助项目(2015-WSW-088) （2015-WSW-088）
吴阶平医学基金资助项目(320.6755.15023). （320.6755.15023）
