重庆医学2017，Vol.46Issue(15)：2045-2047,3.DOI:10.3969/j.issn.1671-8348.2017.15.010
不同HAART方案对HIV合并HCV感染患儿肝功能和HIV载量的影响
The effect of different HAART regimens on liver function and HIV load of HIV infected children with HCV co-infection
摘要
Abstract
Objective To investigate the effect of different HAART regimens on liver function,viral load and CD4+T cells of HIV infected children with HCV co-infection.Methods A total of 40 patients were divided into 4 groups:13 cases in AZT+3TC+NVP group(group A),16 cases in AZT+3TC+EFV group(group B),5 cases in D4T+3TC+EFV group(group C)and 6 cases in D4T+3TC+NVP group(group D).Liver function,viral load and CD4+T cells of patients in 4 groups were compared between before and after HAART.Results Eight patients(20％)had abnormal liver function before HAART treatment,and all of them had 1 level of liver damage.After receiving HAART,levels of ALT and AST were increased in group A and B(P<0.01);AST levels were increased in group C(P<0.01).CD4+T counts were all increased and HIV viral loads were decreased in 4 groups(P<0.01).There was no significant difference in RNA HCV load before and after HAART treatment(P>0.05).Conclusion Different HAART regimens can increase the liver damage in HIV infected children co-infected with HCV,but have little effect on the treatment efficiency of HAART regimens.关键词
HIV/肝炎,丙型/病毒载量/抗逆转录病毒治疗,高效/肝功能Key words
HIV/hepatitis C/viral load/antiretroviral therapy/highly active/liver function分类
医药卫生引用本文复制引用
饶和平,靳昌忠,金祥宁,方美新,王炜,卢伟力..不同HAART方案对HIV合并HCV感染患儿肝功能和HIV载量的影响[J].重庆医学,2017,46(15):2045-2047,3.基金项目
浙江省公益性技术应用研究计划项目(2014C33252) （2014C33252）
衢州市科技计划项目(2013Y019). （2013Y019）
