动物营养学报2017，Vol.29Issue(5)：1489-1497,9.DOI:10.3969/j.issn.1006⁃267x.2017.05.006
肠道对共生微生物的免疫耐受机制
Intestinal Immune Tolerance Mechanism of Symbiotic Microorganisms
摘要
Abstract
There are millions of microorganisms in the intestine of animals. These symbiotic microorganisms can assist digestion and metabolism of organisms and maintain intestinal stability. However, the microorganisms and their metabolites can also serve as an antigen affect the normal function of the intestine. Under normal cir?cumstances, the intestinal immune system can accurately identify symbiotic microorganisms and their metabo?lites to make immune tolerance and maintain the stability of the internal environment. On the other hand, it a?voids reaction to harmless antigens caused by the waste of immune resources. Immune tolerance has been wide?ly used in clinical medicine to reduce the occurrence of rejection after organ transplantation and decrease uterine immune rejection of the fetus. However, there is little report on how to use the immune tolerance mechanism to reduce the rumen acidosis of ruminants and improve the synthesis and utilization efficiency of ruminal microbial protein, and to improve the feeding regulations of probiotics. Therefore, this review describes the general con?cepts and applications of immune tolerance, the composition and function of the intestinal immune system, the immunogenicity of intestinal symbiotic microorganisms and the mechanisms of intestinal immune tolerance.关键词
肠道共生微生物/肠道免疫系统/肠道免疫耐受/作用机制Key words
intestinal symbiotic microorganisms/intestinal immune system/intestinal immune tolerance/mechanism分类
农业科技引用本文复制引用
乐佳清,王佳堃..肠道对共生微生物的免疫耐受机制[J].动物营养学报,2017,29(5):1489-1497,9.基金项目
中央高校基本科研业务费专项资金资助(2015FZA6016) （2015FZA6016）
