动物营养学报2017，Vol.29Issue(5)：1670-1677,8.DOI:10.3969/j.issn.1006⁃267x.2017.05.027
谷氨酰胺对脂多糖应激仔猪生长性能及血清生化指标的影响
Effects of Glutamine on Growth Performance and Serum Biochemical Parameters of Lipopolysaccharide Challenged Piglets
摘要
Abstract
The objective of the study was to evaluate the effects of dietary glutamine ( Gln) supplementation on growth performance in the different stages, and the effects of Gln on growth performance and serum biochemi?cal parameters of weaned piglets after intestinal injury induced by lipopolysaccharide ( LPS ) . Twenty?four cross?bred (Duroc×Landrace×Yorkshire) piglets weaned at 28 days of age were randomly assigned into 3 groups with 8 replicates per group and 1 pig per replicate. Pigs in the control group and LPS group were fed the basal diet, and the others in the Gln+LPS group were fed the basal diet supplemented with 1% exogenous Gln. On day 22, 25, 28 and 30 of the trial, piglets in the LPS and Gln+LPS groups were administered intraperito?neally with 100 μg/kg BW LPS, whereas pigs in the control group were injected intraperitoneally with the same volume of sterile saline. The experiment lasted for 30 days. The results showed as follows: 1 ) before LPS challenge ( day 1 to 21 of the trial) , compared with the control group, the average daily feed intake ( AD?FI) and average daily gain ( ADG) of weaned piglets in Gln+LPS group were significantly increased on day 1 to 7 of the trial ( P<0.05) , the ADFI of weaned piglets in Gln+LPS group was significantly increased on day 8 to 14 and 1 to 21 of the trial (P<0.05). 2) After LPS challenge (day 22 to 30 of the trial), the ADFI, ADG and body weight on day 30 of weaned piglets in control group were significantly higher than those in LPS and Gln+LPS groups ( P<0.05) , the ADFI, ADG and body weight on day 30 of weaned piglets in Gln+LPS group were higher than those in LPS group ( P>0.05) . 3) The small intestine length of weaned piglets in LPS group was significantly lower than that in control and Gln+LPS groups ( P<0.05) , but there was no difference between the control group and Gln+LPS group ( P>0.05) . 4) Compared with the control group, the high den?sity lipoprotein cholesterol content and alkaline phosphatase activity in serum of weaned piglets in Gln+LPS group were significantly decreased (P<0.05), but there was no difference between the Gln+LPS group and LPS group ( P>0.05); the serum immunoglobulin M content of weaned piglets in Gln+LPS and LPS groups was significantly increased ( P<0.05) . The results indicate that dietary supplemented with 1% Gln can improve the growth performance of piglets after weaning 1 to 7 day, and then it is not obvious. Dietary supplemented with 1% Gln can regulate the serum biochemical parameters, improve the growth performance and small intes?tine length of piglets, thereby alleviate weaning stress.关键词
谷氨酰胺/仔猪/脂多糖/生长性能/血清生化指标Key words
glutamine/weaned piglets/LPS/growth performance/serum biochemical parameters分类
农业科技引用本文复制引用
田军权,何流琴,黄牛,李欢,崔志杰,李思,姚康..谷氨酰胺对脂多糖应激仔猪生长性能及血清生化指标的影响[J].动物营养学报,2017,29(5):1670-1677,8.基金项目
国家973课题(2013CB127301) （2013CB127301）
中科院百人计划项目 （）
国家自然科学基金面上项目(31472107) （31472107）
