广东医学2017，Vol.38Issue(7)：1009-1013,5.
急性淋巴细胞白血病患者血清乳酸脱氢酶和维生素D水平与其预后的关系
The correlation of serum lactate dehydrogenase and vitamin D levels with prognosis of patients with acute lymphocytic leukemia
摘要
Abstract
Objective To investigate the correlation between serum lactate dehydrogenase (LDH) or vitamin D and prognosis of patients with acute lymphocytic leukemia (ALL).Methods Sixty-three adult patients with ALL and had first time treatment were selected as ALL group,whom were treated with high-dose methotrexate therapy and followed up for at least 1 year.And 30 healthy volunteers had physical exam in the same period were selected as control group.Serum LDH and 25-hydroxyl vitamin D [25 (OH)D] levels,and acute physiology and chronic health evaluation (APACHE Ⅱ) were assessed and compared.One-year survival prognosis of ALL group was statistically analyzed.Correlation between serum LDH and 25 (OH) D levels with the APACHE Ⅱ scores and 1-year survival rate of ALL patients were analyzed.Results Before treatment,serum LDH level and APACHE Ⅱ scores in ALL group were significantly higher than control group,while serum 25 (OH) D level was lower (P ＜ 0.05).Compared with before treatment,serum LDH level and APACHE Ⅱ scores in ALL group were significantly lower 3 days and 1 month after treatment,while the serum 25 (OH)D levels were significantly elevated (P ＜0.05).The 1-year survival rate in ALL group was 80.95％.Compared with survive patients in ALL group,serum LDH levels and APACHE Ⅱ scores before and after treatment in death patients were significantly higher,while serum 25 (OH)D levels were per contra (P ＜ 0.05).Unconditional Spearman correlation analysis results showed that serum LDH level in ALL patients was significantly positively correlated with APACHE Ⅱ scores (r =0.868,P ＜ 0.05),while negatively correlated with 1-year survival rate (r =-0.892,P ＜ 0.05);and serum 25 (OH) D level was significantly negatively correlated with APACHE Ⅱ scores (r =-0.705,P ＜ 0.05),while positively correlated with 1-year survival rates (r =0.826,P ＜ 0.05).According to the results of ROC curve analysis,accuracies of serum LDH combined with 25 (OH) D level before treatment,and 3 d and 1 month after treatment in predicting 1-year survival prognosis for ALL were 88.89％,95.24％ and 98.41％,respectively.Conclusion Serum LDH level and 25 (OH)D level of ALL patients are associated with disease severity and the prognosis,and value of them combined predicting prognosis is good.关键词
急性淋巴细胞白血病/乳酸脱氢酶/维生素D/预后/关系Key words
acute lymphoblastic leukemia/lactate dehydrogenase/vitamin D/prognosis/relationship引用本文复制引用
吴必嘉,龚峻梅,陈娟娟,郭天剑,方明,黄斯勇..急性淋巴细胞白血病患者血清乳酸脱氢酶和维生素D水平与其预后的关系[J].广东医学,2017,38(7):1009-1013,5.基金项目
国家自然科学基金资助项目(编号:81300397) （编号:81300397）
