广东医学2017，Vol.38Issue(10)：1519-1522,1527,5.
瘦素抵抗与高血压左室肥厚及动脉粥样硬化的相关性
Correlation analysis of leptin resistance, hypertensive left ventricular hypertrophy and atherosclerosis
摘要
Abstract
Objective To analyze the correlations between leptin resistance with left ventricular hypertrophy (LVH) and atherosclerosis (AS) in hypertension.Methods Serum leptin and SLR levels of 80 patients with essential hypertension (EH) and 40 healthy subjects were assessed by enzyme-linked immunosorbent assay (ELISA).UCG was performed in all subjects for left ventricular mass index (LVMI) and carotid intima media thickness (cIMT).The participants were divided into hypertensive left ventricular hypertrophy group (HLVH group, n=40), essential hypertension without LVH group (non-LVH group, n=40), healthy subjects (control group, n=40) based on LVMI.Meanwhile, they were divided into thickened cIMT group (n=61) and normal cIMT group (n=59) base on cIMT.Results Serum leptin level was significantly higher in non-LVH group than control group;higher in HLVH group than non-LVH and control groups (P<0.05).Serum SLR was significantly lower in non-LVH group than control group;lower in HLVH group than non-LVH and control groups (P<0.05).Serum leptin level was significantly higher in thickened cIMT group than normal cIMT group (P<0.05).Serum SLR was significantly lower in thickened cIMT group than normal cIMT group (P<0.05).Serum leptin level was positively correlated with LVMI and cIMT (r=0.757 and 0.694, P<0.001), whereas serum SLR level was negatively correlated with LVMI and cIMT (r=-0.682 and-0.708, P<0.001).Conclusion Serum leptin and SLR levels are closely associated with LVMI and cIMT, indicating a possible role of leptin resistance closely related the development and progression of LVH and AS in hypertension.关键词
瘦素/可溶性瘦素受体/瘦素抵抗/高血压/左室肥厚/动脉粥样硬化Key words
leptin/soluble leptin receptor/leptin resistance/hypertension/left ventricular hypertrophy/atherosclerosis引用本文复制引用
胡迪聃,徐彤彤..瘦素抵抗与高血压左室肥厚及动脉粥样硬化的相关性[J].广东医学,2017,38(10):1519-1522,1527,5.基金项目
广西科学研究与技术开发计划项目(编号:桂科能1598025-29) （编号:桂科能1598025-29）
