中国妇幼健康研究2017，Vol.28Issue(5)：547-549,576,4.DOI:10.3969/j.issn.1673-5293.2017.05.020
妊娠期高血压疾病血ET-1与NO水平变化及其对肾动脉血流动力学的影响
Changes of serum ET-1 and NO levels in patients with hypertensive disorder complicating pregnancy and their effects on renal artery hemodynamics
摘要
Abstract
Objective To investigate the changes of plasma endothelin-1 (ET-1) and nitric oxide (NO) levels in patients with hypertensive disorder complicating pregnancy (HDCP) and their effects on renal function.Methods Altogether 120 patients with HDCP admitted from December 2014 to December 2016 were enrolled in this study.According to severity of disease, they were divided into gestational hypertension group (n=45) and preeclampsia group (n=75), and preeclampsia group was further divided into mild group (n=40) and severe group (n=35).At the same time, 40 healthy pregnant women were randomly selected and matched as control group.Changes of plasma ET-1 and NO levels in pregnant women and their correlation with renal function and renal artery hemodynamics were analyzed.Results The more severe HDCP was, the higher plasma ET-1 level (F=219.70, P<0.01), and the lower plasma NO level (F=292.00, P<0.01).The more severe HDCP was, the higher levels of plasma BUN (F=8.33, P<0.01), Scr (F=384.90, P<0.01), blood urea (F=89.66, P<0.01) and serum uric acid (F=560.00, P<0.01).There was no significant difference in PSV among four groups (F=0.02, P=0.99).EDV, RI, PI and S/D of patients with preeclampsia were significantly higher than those of women in gestational hypertension group and control group, and the differences were statistically significant (P<0.05).Level of ET-1 was positively correlated with BUN, Scr, blood urea, blood uric acid, RI, PI and S/D levels (r value ranged 1.55-4.54, all P<0.05), and negatively correlated with EDV (r=-3.80, P=0.04).However, level of NO was positively correlated with EDV (r=4.25, P=0.02), and negatively correlated with BUN, Scr, blood urea, blood uric acid, RI, PI and S/D levels (r value ranged-1.84--3.94, all P<0.05).There was no significant correlation between ET-1, NO levels and PSV (r value was 1.60 and 0.70, respectively, both P>0.05).Conclusion With aggravation of HDCP, plasma ET-1 levels are significantly higher and plasma NO levels are significantly lower, afferent arteriole constriction more obvious, and renal injury more severe.关键词
妊娠期高血压疾病/内皮素-1/一氧化氮/血管内皮细胞/肾功能/肾动脉血流动力学Key words
hypertensive disorder complicating pregnancy (HDCP)/endothelin-1 (ET-1)/nitric oxide (NO)/vascular endothelial cell/renal function/renal arterial hemodynamics分类
医药卫生引用本文复制引用
沈晓翀,赵长伟,姚健..妊娠期高血压疾病血ET-1与NO水平变化及其对肾动脉血流动力学的影响[J].中国妇幼健康研究,2017,28(5):547-549,576,4.基金项目
秀洲区科技计划资助项目(2016C003) （2016C003）
