中国妇幼健康研究2017，Vol.28Issue(5)：584-586,3.DOI:10.3969/j.issn.1673-5293.2017.05.032
孕中期预防性应用维生素D降低妊娠期糖尿病发病率的临床效果
Clinical effect of prophylactic use of vitamin D in the second trimester to reduce the incidence of gestational diabetes mellitus
摘要
Abstract
Objective To analyze the clinical effect of prophylactic use of vitamin D in the second trimester on reducing the incidence of gestational diabetes mellitus (GDM).Methods Totally 120 women with 12 weeks of pregnancy admitted in Leliu Hospital in Foshan City during August 2014 to March 2015 were selected.All the patients were divided into intervention group and control group according to random number table with 60 cases in each group.Beginning from 12 gestational weeks, the patients in the intervention group were injected 200000 IU of vitamin D into muscle once every month, which lasted for 3 months, while the patients in the control group were given placebo.The treatment lasted till 24 weeks of pregnancy.Fasting blood glucose levels, fasting insulin concentration, 25 hydroxyl vitamin D3 levels in serum were retested.And OGTT experiment was carried out to determine the incidence of GDM in two groups.The 25 hydroxyl vitamin D3 levels in serum, blood glucose levels and incidence of GDM were observed and compared between two groups.Results There was no significant difference in 25 hydroxyl vitamin D3 levels in serum of patients with 12 weeks of pregnancy between two groups (t=1.32, P>0.05).After treatment with vitamin D supplementation, 25 hydroxyl vitamin D3 levels in serum of patients in the intervention group were significantly higher than those in the control group at 24 weeks of pregnancy (t=5.31, P<0.05).In intervention group, 25 hydroxyl vitamin D3 levels in serum at 24 weeks were higher than those at 12 weeks, while in the control group, 25 hydroxyl vitamin D3 levels in serum at 24 weeks were lower than those at 12 weeks.But there was no significant difference between two groups (t value was-1.79 and 1.83, respectively, both P>0.05).At 12 weeks of pregnancy, there was no significant difference in fasting blood glucose, fasting insulin level and insulin resistance index between two groups (t value was 0.93, 0.77 and 0.46, respectively, all P>0.05).At 24 weeks of pregnancy, fasting blood glucose, fasting insulin level and insulin resistance index of patients in the intervention group were significantly lower than those in the control group (t value was-4.54,-5.31 and-5.57, respectively, all P<0.05), and the incidence of GDM in the intervention group was significantly lower (χ2=17.42, P<0.05).Conclusion The prophylactic use of vitamin D in the second trimester can significantly reduce the incidence of GDM and reach a remarkable clinical effect, which is worthy of popularization and application.关键词
维生素D/妊娠期糖尿病/胰岛素/孕中期Key words
vitamin D/gestational diabetes mellitus (GDM)/insulin/the second trimester分类
医药卫生引用本文复制引用
刘佳,杨春波,李現玲,梁妙,莹马胜..孕中期预防性应用维生素D降低妊娠期糖尿病发病率的临床效果[J].中国妇幼健康研究,2017,28(5):584-586,3.基金项目
广东省佛山市科技局资助项目(编号:2014032) （编号:2014032）
