郑州大学学报（医学版）2017，Vol.52Issue(3)：255-258,4.DOI:10.13705/j.issn.1671-6825.2017.03.004
食管鳞癌组织中AMPKα1及磷酸化AMPKα的表达
Expressions of AMPKα1 and p-AMPKα in esophageal squamous cell carcinoma tissue
摘要
Abstract
Aim: To discuss the expression of adenosine 5′-monophosphate-activated protein kinase(AMPK) in esophageal squamous cell carcinoma(ESCC) tissue and its clinical significance.Methods: The ESCC and normal esophageal mucosal epithelial tissue samples were collected from 61 ESCC patients, and the expressions of AMPKα1 and p-AMPKα were detected by immunohistochemical SP method.Results: The AMPKα1 positive expression rate in ESCC tissue had no significant difference compared with the normal esophageal mucosa tissue(P>0.05),and that among different clinical and pathological characteristics ESCC tissue had no significant difference(P>0.05).The positive expression rate of p-AMPKα in ESCC tissue(32.7%) was lower than that of normal esophageal mucosa tissue(73.7%), and that in poor differentiated ESCC tissue was lower than that in medium and high differentiated tissue(P<0.05).There was no correlation between the expressions of p-AMPKα and AMPKα1 in ESCC tissue(rP=0.228,P>0.05).Conclusion: Abnormal activation of AMPK pathway may be related to the occurrence and development of ESCC.关键词
腺苷酸活化的蛋白激酶/食管癌/能量代谢Key words
AMPK/esophageal carcinoma/energy metabolism分类
医药卫生引用本文复制引用
郭幸,刘宗文,张艳,郭振江,楚阿兰,宋锐,侯歌,袁金金,王成..食管鳞癌组织中AMPKα1及磷酸化AMPKα的表达[J].郑州大学学报（医学版）,2017,52(3):255-258,4.基金项目
河南省基础与前沿技术研究计划项目 132300410409 （）
河南省医学科技攻关计划项目(省部共建项目) 201401009 （省部共建项目）
郑州市科技计划项目 131PCXTD628 （）
