郑州大学学报（医学版）2017，Vol.52Issue(3)：285-290,6.DOI:10.13705/j.issn.1671-6825.2017.03.011
肿瘤床出血的非典型垂体腺瘤组织中Ki-67与CD34的表达
Expressions of Ki-67 and CD34 in tissue from atypical pituitary adenoma with tumor bed bleeding
摘要
Abstract
Aim: To investigate the expression of CD34 in atypical pituitary adenoma(APA) tissue with tumor bed blooding(TBB) and its relationship with TBB.Methods: A total of 194 cases of pituitary adenomas accepting surgery were collected and the expressions of Ki-67 and CD34 were detected by immunohistochemical method.The clinical data, MRI manifestation and immunohistochemical features of 17 cases of APA were studied.The relationship between TBB during the operation and CD34 expression was analyzed.Results: The 17 APA were all macro-adenoma.Among them,14 APA with gross-total resection underwent few to moderate TBB during the operation and 2 APA with subtotal resection experienced severe TBB.Most MRI manifestations of APA were iso-intensity on T1WI and iso-hyperintensity on T2WI with obvious enhancement.Ki-67 LI of 17 cases of APA were 3.2%~12.0%.The positive expression values of CD34 were (26.8±7.7) and (10.6±5.3) in 16 cases of APA with TBB and pituitary adenomas without TBB(P=0.025).Conclusion: The combination of CD34 positive expression and hypervascular MRI manifestation helps to understand the mechanism of TBB, judge and predict the prognosis of APA.关键词
非典型垂体腺瘤/肿瘤床出血/Ki-67/CD34Key words
atypical pituitary adenoma/tumor bed blooding/Ki-67/CD34分类
医药卫生引用本文复制引用
张岚,郭付有..肿瘤床出血的非典型垂体腺瘤组织中Ki-67与CD34的表达[J].郑州大学学报（医学版）,2017,52(3):285-290,6.基金项目
国家自然科学基金资助项目 U1204807 （）
河南省中医药科学研究专项课题 2015ZY02014 （）
