郑州大学学报（医学版）2017，Vol.52Issue(3)：344-348,5.DOI:10.13705/j.issn.1671-6825.2017.03.025
强迫症患者症状严重程度与脑功能活动的关系
Correlation between severity of symptoms and activation pattern of brain neurons in patients with obsessive-compulsive disorder
摘要
Abstract
Aim: To explore the correlation between the severity of symptoms of patients with obsessive-compulsive disorder (OCD) and the activation pattern of brain neurons at resting.Methods: A total of 26 patients diagnosed as first-episode OCD were selected and underwent functional magnetic resonance imaging(fMRI) scanning at resting state.The fMRI data were processed by SPM8, DPARSFA, and REST software.With age as concomitant variable, Pearson correlation analysis was adopted to study the correlation between the severity of symptoms of patients and their regional homogeneity (ReHo) values of whole brain.Results: The positive correlation between the severity of symptoms of patients with OCD and ReHo value lied in frontal_inf_L, frontal_inf_R, frontal_mid_L, frontal_mid_R, precentral_R, frontal_sup_L, temporal_mid_L, temporal_Sup_R.The negative correlation between the severity of symptoms of patients with OCD and ReHo value lied in caudate_L, caudate_R, thalamus_L, cingulum_L, cingulum_R, precuneus_L.Conclusion: When the symptoms of OCD patients are aggravated, the function of cortico-striatal-thalamo-cortical(CSTC) becomes tangled, and the dysfunction of lobi temporal is and precuneus outside CSTC indirectly contributes to the occurrence and development of OCD.关键词
强迫症/症状严重程度/静息态功能磁共振/局部一致性Key words
obsessive-compulsive disorder/severity of symptom/resting-state functional magnetic resonance imaging/regional homogeneity引用本文复制引用
牛琪惠,李幼辉,程敬亮,宋学勤,杨磊,初从颖,刘浩,张力方,李妍..强迫症患者症状严重程度与脑功能活动的关系[J].郑州大学学报（医学版）,2017,52(3):344-348,5.基金项目
河南省科技重大攻关项目 142102310512 （）
西部精神医学协会科研基金资助 Wcpafund-201608 （）
