中国实用神经疾病杂志2017，Vol.20Issue(11)：24-27,4.
重组人血管内皮抑素联合放化疗治疗高级别人脑胶质瘤的临床疗效
Clinicaleffect of recombinant human endostatin combined radiotherapy and chemotherapy for high-grade gliomas
靳彩玲 1赵树鹏 2杨军 1陈美玲 1亢晓春 1牛红蕊 1张敏1
作者信息
- 1. 新乡医学院第一附属医院肿瘤科 卫辉 453100
- 2. 新乡医学院第一附属医院神经外科 卫辉 453100
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy and safety of recombinant human endostatin combined radiotherapy and chemotherapy for high-grade gliomas.Methods Totally 80 cases of brain glioma from January 2012 to December 2014 in the First Hospital of Xinxiang Medical College were divided into control group and observation group,40 cases in each group.The control group adopted radiotherapy combined with temozolomide chemotherapy,observation group applied recombinant human endostatin based on the control group.The patients were followed up for 2 years,and the objective curative effect and the safety of drugs were evaluated.Results The effective rate of the control group and the observation group were 45% and 70%,respectively,the difference was statistically significant (P<0.05).The one-year and two-year survival rate was 50%,35% and 72.5%,62.5%,respectively.The difference of survival rate between two groups was statistically significant (P<0.05).The adverse reactions were mostly from gradeⅠto grade Ⅱ.No grade Ⅲ or more adverse reactions were observed.There was no significant difference on adverse reactions (P>0.05).Conclusion Recombinant human endostatin combined radiotherapy and chemotherapy for high grade gliomas can significantly improve the short-and long-term clinical efficacy with a certain safety.It was worth for further clinical study.关键词
胶质瘤/调强放疗/重组人血管内皮抑素/替莫唑胺Key words
Glioma/Intensity modulated radiothempy/Recombinant human endostatin/Temozolomide capsule分类
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靳彩玲,赵树鹏,杨军,陈美玲,亢晓春,牛红蕊,张敏..重组人血管内皮抑素联合放化疗治疗高级别人脑胶质瘤的临床疗效[J].中国实用神经疾病杂志,2017,20(11):24-27,4.
