摘要
Abstract
Objective To investigate effects of topiramate and sodium valproate on six constant/trace elements in serum of children with epilepsy.Methods Eighty children with epilepsy participated in the study.40 cases were treated with TPM monotherapy,and 40 cases were treated with VPA monotherapy.40 healthy children were selected as normal control.Magnesium,zinc,copper,calcium,iron and lead levels were assayed before and after six months of treatment.Results Children with epilepsy had significant low levels of calcium,iron and zinc(1.45±0.40)mmol/L,(7.25±2.16)mmol/L and(69.88±10.99)μmol/L,respectively,and the corresponding values for controls were(1.66±0.45)mmol/L,(8.26±2.65)mmol/L and(78.24±12.44)μmol/L,respectively.Compared with the control group,there was no significant difference in the content of copper,magnesium and lead in children with epilepsy.There were no significant differences in the content of copper,zinc,magnesium,calcium,iron and lead between the VPA group and the TPM group before treatment.There was no significant difference in the contents of various elements in the two groups after treatment.There was no significant difference in the content of various elements in children with epilepsy before and after treatment.Conclusion Serum zinc,calcium and iron levels are significantly decreased in children with epilepsy.VPA and TPM treatment have no significant effect on serum magnesium,zinc,copper,calcium,iron and lead content in children with epilepsy.关键词
癫痫/丙戊酸钠/托吡酯/镁/锌/铜/钙/铁/铅Key words
Epilepsy/Sodium valproate/Topiramate/Magnesium/Zinc/Copper/Calcium/Iron/Lead分类
医药卫生
