四川大学学报（医学版）2017，Vol.48Issue(3)：422-426,5.
降钙素原、超敏C反应蛋白、胰石蛋白联合检测对脓毒症患儿预后的预测价值
Value of Procalcitonin, High Sensitivity C-reactive Protein and Pancreatic Stone Protein in Predicting Prognosis of Children with Sepsis
摘要
Abstract
Objective To determine the value of procalcitonin (PCT),high sensitivity C-reactive protein (hs-CRP) and pancreatic stone protein(PSP) in predicting the prognosis of children with sepsis.Methods A total of 106 hospitalized children [(4.4± 1.6) year-old] with sepsis were enrolled in this study.The expressions of PTC,hs-CRP and PSP in the serum samples of the children were detected on the first day of admission to hospital.Pearson correlation analyses were performed to test the correlations between pediatric critical illness score (PCIS) and PTC,hs-CRP and PSP.Logistic regression models were established to determine factors predicting death of children.The value of PTC,hs-CRP and PSP in predicting the prognosis of children with sepsis was determined using ROC curves.Results About 32％ children (34 cases) died.Higher expressions of PTC,hs-CRP and PSP were found in those who died (P＜0.001).Serum PTC,hs-CRP and PSP were negatively correlated with PCIS (P＜0.001).The multivariate logistic regression showed that PTC,hs-CRP and PSP were independent predictors of death in patients with sepsis (P＜0.001).PTC,hs-CRP and PSP had an area under the curve (AUC) value of 0.86[(95％ confidence interval (CI),0.78-0.92],0.70(95％CI,0.61-0.79) and 0.69(95％CI,0.60-0.78),respectively.The AUC value increased (P ＜ 0.001) to 0.92 (95 ％ CI,0.85-0.96) when the three indicators were combined (0.481 × PCT+0.392 × hs CRP + 0.314 * PSP),with a value of less than 122.3 indicating good prognosis in 28 d.Conclusion Serum PTC,hs-CRP and PSP can predict prognosis of children with sepsis.关键词
脓毒症/降钙素原/超敏C反应蛋白/胰石蛋白Key words
Sepsis/Procalcitonin/High sensitivity C-reactive protein/Pancreatic stone protein引用本文复制引用
霍俊明,霍锐,胡玲,卢思为,祖建..降钙素原、超敏C反应蛋白、胰石蛋白联合检测对脓毒症患儿预后的预测价值[J].四川大学学报（医学版）,2017,48(3):422-426,5.基金项目
重庆市卫计委中医药科技项目(No.ZY201402043)资助 （No.ZY201402043）
