检验医学与临床2017，Vol.14Issue(10)：1363-1365,3.DOI:10.3969/j.issn.1672-9455.2017.10.001
四川地区冠心病患者CYP2C19基因多态性检测
Genetic polymorphism analysis of CYP2C19 in patients with coronary heart disease in Sichuan Province
摘要
Abstract
Objective To detect the CYP2C19 gene polymorphisms in patients with coronary heart disease (CHD) in Sichuan Province,and to analyze the correlation of its genotype with gender,age and clinical classification.Methods By DNA microarray chip,CYP2C19 gene type of total 131 cases,including 90 males and 41 females,diagnosed with CHD were detected.The correlation of CYP2C19 gene polymorphisms with gender,age and clinical classification was statistically analyzed.Results In the 131 cases of CHD patients,five genotypes were detected,including CYP2C19*1/*1 (636GG,681GG),CYP2C19*1/*2 (636GG,681GA),CYP2C19*1/*3 (636GA,681GG),CYP2C19*2/*2 (636GG,681AA) and CYP2C19*2/*3 (636GA,681GA).The distribution of genotypes were 53 cases (40.5%),54 cases (41.2%),6 cases (4.6%),13 cases (9.9%) and 5 cases (3.8%),respectively.CYP2C19*3/*3 (636AA,681GG) was not detected.The CYP2C19 genotypes and allele frequency between different genders had no statistical difference in CHD patients (P>0.05),while CYP2C19 metabolic type distributions between male and female CHD patients had significant difference (χ2=6.527,P=0.038).Different age groups and different CHD clinical sub-type patients had no statistical difference in CYP2C19 genotypes,allele frequency and metabolic type distribution (P>0.05),respectively.Conclusion CYP2C19 genotype distribution,allele frequency and metabolic type distribution among the CHD patients have no correlation with genders,age and CHD clinical sub-types.关键词
CYP2C19/冠心病/基因芯片/基因多态性Key words
CYP2C19/coronary heart disease/gene chip/gene polymorphism引用本文复制引用
曾敏,熊怡淞,俞娟,常凯,吴艾霖..四川地区冠心病患者CYP2C19基因多态性检测[J].检验医学与临床,2017,14(10):1363-1365,3.基金项目
国家自然科学基金资助项目(81302596,81301484) （81302596,81301484）
成都军区总医院院管课题(2013YG-B064). （2013YG-B064）
