摘要
Abstract
Objective To discuss and study on the detection results of immune indexes in children with refractory Mycoplasma pneumonia,and to analyze their significance.Methods Forty-two cases of children with refractory Mycoplasma pneumonia and 46 cases of children with common Mycoplasma pneumonia were respectively noted as the experimental A group and experimental B group,and another 50 cases of healthy volunteers with the same age segment were noted as the control group.The indicators of immune cells (including CD3+,CD4+,CD8+,CD19+,CD4+/CD8+ and CD16+CD56+) and indicators of humoral immunity (including IgA,IgG and IgM) in the three groups were respectively detected by flow cytometry and micro immunoassay.All of the children in the experimental A group and experimental B group were given symptomatic supportive treatment,and the changes of cellular and humoral immune index in the two groups before and after treatment and control group were compared.The children in the experimental A group were divided into two sub-groups according to the prognosis effect,between which the levels of immune indexes were compared.Results The levels of CD8+,CD19+,IgA,IgG and IgM in the experimental A group and experimental B group before treatment were significantly higher than those in the control group (P<0.05),while the levels of CD3+,CD4+,CD4+/CD8+ and CD16+CD56+ were significantly lower than those in the control group (P<0.05),and there were significant differences between the experimental A group and the experimental B group (P<0.05).The levels of CD8+,CD19+,IgA,IgG and IgM in the experimental A group and experimental B group after treatment were significantly decreased compared with those before treatment (P<0.05),while the levels of CD3+,CD4+,CD4+/CD8+,CD16+CD56+ were significantly decreased (P<0.05),and there were significant differences between the experimental A group and the experimental B group (P<0.05).There were 34 cases of good prognosis in the experimental A group,of which the rate was 80.95%.The levels of CD3+,CD4+,CD4+/CD8+ and CD16+CD56+ in the good prognosis group were significantly higher than those in the poor prognosis group (P<0.05),while the levels of CD8+,CD19+,IgA,IgG and IgM were significantly lower than those in the poor prognosis group (P<0.05).Conclusion The levels of cellular immunity and humoral immunity indexes in children with refractory Mycoplasma pneumonia are obviously abnormal,which can provide reference for guiding treatment and prognosis evaluation.关键词
难治性支原体肺炎/普通支原体肺炎/细胞免疫/体液免疫Key words
refractory Mycoplasma pneumonia/common Mycoplasma pneumonia/cellular immunity/humoral immunity
