摘要
Abstract
Objective To investigate the expression and clinical significance of soluble endothelial growth factor (sEng),soluble Fms-like tyrosine kinase-1 (sFlt-1),angiotensin Ⅱ receptor autoantibodies (AT1-AA) in patients with preeclampsia.Methods A total of 85 patients with preeclampsia (45 cases with mild preeclampsia,40 cases with severe preeclampsia) and 80 cases of healthy pregnant women (control group) were selected from January 2015 to December 2015.The levels of sEng,sFIt-1 and AT1-AA were detected by ELISA.The correlation of each index was analyzed with Pearson correlation.The diagnostic values of sEng,sFIt-1 and AT1-AA in preeclampsia were analyzed by receiver operating characteristic (ROC).Results The levels of sEng,sFIt-1 and AT1-AA of maternal blood and cord blood of newborns of severe preeclampsia group and mild preeclampsia were significantly higher than of control group (P<0.05),and the levels of sEng,sFIt-1 and AT1-AA of severe preeclampsia group were significantly higher than that of mild preeclampsia group (P<0.05).The level of sEng was positively correlated with sFIt-1 and AT1-AA (P<0.05),sFIt-1 was positively correlated with AT1-AA (P<0.05).The sensitivity and specificity of sEng,sFIt-1,AT1-AA were 76.3% and 85.5%,79.2% and 85.6%,70.8% and 82.2% by ROC analysis.Conclusion Maternal blood,cord blood sEng,sFIt-1 and AT1-AA in patients with preeclampsia are closely related with preeclampsia and progress,these indicators can be used to diagnose of preeclampsia,as well as predictors of preeclampsia and progress.关键词
可溶性内皮因子/可溶性Fms样酪氨酸激酶-1/血管紧张素Ⅱ型受体自身抗体/子痫前期Key words
soluble endothelial growth factor/soluble Fms-like tyrosine kinase-1/angiotensin Ⅱ receptor autoantibodies/preeclampsia
