昆明医科大学学报2017，Vol.38Issue(1)：1-7,7.
2种不同方法制备的紫杉醇壳聚糖缓释膜的药物缓释特性对比
Comparative Study on Releasing Characteristics of Paclitaxel Chitosan Membranes by Two Different Preparative Methods
摘要
Abstract
Objective To compare the sustained release characteristics of paclitaxel chitosan membranes prepared by two different methods.Methods We prepared PTX-Suc-HECTS sustained release film and P-PTX-SRM release film by different methods.Then we measured the PTX loaded in chitosan membrane with FTIR,measured the best of factors for equilibrium swelling degree in the two sustained release membranes with multifactors orthogonal experiment,measured the standard curve of PTX,measured the two sustained release membrane in vitro PTX release curve.According to the standard curve,we also measured and compared the drug rate between two kinds of sustained-release film release in vitro.Results PTX was loaded in the chitosan sustained release film.The best of equilibrium swelling factors for PTX-Suc-HECTS sustained-release membrane were 250 mg Suc-HECTS,1 mg/mL EDC-HCl and DMAP aqueous solution,1h the cross-linking time,1 ∶ 100 cross-linking ratio.The best of equilibrium swelling factors for P-PTX-SRM sustained release membrane were 1％ dilute acetic acid,1h crosslinking time,1 ∶ 100 crosslinking ratio;the two sustained release membranes had bursting diaphragm part and sustained release part in vitro,but burst rate of PTX-Suc-HECTS was lower than P-PTX-SRM (P＜0.05),and there was no statistical difference between the release parts,(P＞0.05).The higher crosslinking ratio,the less drug release in burst release stage in 48h,and more drug release in sustained release stage in unit time.Conclusion PTX-Suc-HECTS sustained release membrane and P-PTX-SRM sustained release membrane have good sustained-release characteristics,P-PTX-SRM has the advantages of simple preparation process,short preparation time and saving experiment time,so it can be a preferred method to prepare the chitosan membrane.关键词
壳聚糖缓释膜/紫杉醇/药物/方法Key words
Chitosan sustain film/PTX/Drug/Methods分类
医药卫生引用本文复制引用
宋飞,向盈盈,毛志坚,张小文..2种不同方法制备的紫杉醇壳聚糖缓释膜的药物缓释特性对比[J].昆明医科大学学报,2017,38(1):1-7,7.基金项目
国家自然科学基金资助项目(81260084) （81260084）
