昆明医科大学学报2017，Vol.38Issue(1)：41-45,5.
透析患者微炎症状态与血脂代谢及钙磷代谢的相关性
Correlation of Serum Lipid Metabolism, Calcium and Phosphorus Metabolism in Hemodialysis Patients with Micro Inflammatory State
摘要
Abstract
Objective To study the correlation of micro inflammation state with serum lipid metabolism,calcium and phosphorus metabolism in hemodialysis patients and its clinical significance.Methods We selected 31 uremic peritoneal dialysis patients (peritoneal dialysis group:PD group),31 continuous hemodialysis patients (hemodialysis group:HD group),and 18 healthy subjects (control group).ELISA method was used to detect serum level of high sensitive C reactive protein (hs-CRP).Automatic biochemical analyzer was used to detect the serum creatinine,urea nitrogen,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,triglyceride,serum calcium,phosphorus,parathyroid hormone,and the results were analyzed.Results Compared with the normal control group,HD group and PD group patients had higher blood hs-CRP,the difference was statistically significant (P＜0.05).Total cholesterol,serum phosphorus,parathyroid hormone and calcium phosphate product of patients in HD and PD groups were higher than those of the control group,the difference was statistically significant (P ＜0.05).There was no statistically significant difference between the normal control group and the HD group or the PD group in low density lipoprotein cholesterol and triglyceride (P＞ 0.05).PD group of patients had a positive correlation between triglyceride and hs-CRP (r=0.36,P＜0.05),there was no significant correlation between other indexes serum lipid,calcium phosphorus metabolism and hs-CRP (P＞ 0.05).Conclusions Micro inflammatory state exsists in patients with chronic dialysis,accompanied by abnormal metabolism of serum lipids and calcium and phosphorus metabolism,but hs-CRP is not significantly correlated with lipid,calcium and phosphorus metabolism.关键词
钙磷代谢/血脂代谢/微炎症状态/血液透析/腹膜透析Key words
Calcium-phosphorus metabolism/Lipids metabolism/Microinflammatory state/Hemodialy sis/Peritoneal dialysis分类
医药卫生引用本文复制引用
茶春丽,李靖娟,陈国姝,窦丽娜,代留玲,李俊..透析患者微炎症状态与血脂代谢及钙磷代谢的相关性[J].昆明医科大学学报,2017,38(1):41-45,5.基金项目
云南省应用基础研究计划项目(2012FB029) （2012FB029）
云南省科技计划基金资助项目(2012FB161) （2012FB161）
昆明医科大学研究生创新基金资助项目(2016S22) （2016S22）
