昆明医科大学学报2017，Vol.38Issue(2)：118-121,4.
右美托咪定对平稳拔除气管导管时七氟烷半数有效浓度的影响
Effects of Dexmedetomidine on Sevoflurane Median Effective Concentration during Extubation
摘要
Abstract
Objective To investigate the effects on sevoflurane median effective concentration (EC50) of intraoperative dexmedetomidine during postoperative extubation and the effects of awaking quality,to explore the feasibility of dexmedetomidine and to improve the quality of recovery from general anesthesia.Methods 60 patients were randomly divided into two groups (n=30) Dexmedetomidine group:1 μg/kg intravenous infusion of dexmedetomidine after induction.Control group:the same amount of normal saline injection after induction.At the end of the operation,sevoflurane concentrations of tracheal extubation was determined according to the Dixon sequential method,while extubating time,waking time,the time of Ramsay score of 3 points and 1 point and complications were observed.Results There was no significant difference in general data between the two groups (P＞0.05).Sevoflurane EC50 of dexmedetomidine group and control group were 0.22 MAC and 0.61 MAC,the 95％ confidence interval was (0.14 ～ 0.30) MAC and MAC (0.47 ～ 0.75),and there were significant differences between the two groups (P＜0.01).There was no significant difference in extubating time,waking time,the time of Ramsay score of 3 points,1 point between the two groups (P＞0.05).There were statistically significant differences in the number of complications between the two groups (P ＜0.05) Conclusions Application of dexmedetomidine can reduce the sevoflurane EC50 during extubation without side effect on the recovery time of patients,decrease the incidence of respiratory depression after extubation,and improve the recovery quality.关键词
右美托咪定/七氟烷/全身麻醉/苏醒Key words
Dexmedetomidine/Sevoflurane/Median effective concentration/General anesthesia分类
医药卫生引用本文复制引用
李文锋,范晓华,董发团,李娜..右美托咪定对平稳拔除气管导管时七氟烷半数有效浓度的影响[J].昆明医科大学学报,2017,38(2):118-121,4.基金项目
上海市自然科学基金资助项目(13ZR1408400) （13ZR1408400）
