山东中医杂志2017，Vol.36Issue(5)：407-410,4.
加味膈下逐瘀汤对肝纤维化模型大鼠肝功能及纤维化指标的影响
Effect of Jiawei Gexia Zhuyu Decoction on Liver Function and Hepatic Fibrosis Index of Model Rats of Hepatic Fibrosis
摘要
Abstract
Objective:To study the effect of Jiawei Gexia Zhuyu decoction(JGZD) on liver fibrosis and its action mechanism.Methods:The rats were divided into normal group,model group,colchicine group and JGZD group,with 10 rats in each group.The colchicine group was given colchicines and the dosage was 1 mg/kg.The JGZD group was given JGZD by gavage and the dosage was equal to that of crude medicine.The normal group and the model group were given saline of the same volume.The organ coefficients of liver was tested and the serum was inspected for getting liver function and liver fibrosis index.The sections of liver tissues were stained by HE to observe the histopathological changes.Results:Compared with the model group,the liver fibrosis of rats in the JGZD group were significantly improved;the organ coefficients of liver of rats in JGZD group were significantly decreased;the levels of alamine aminotransferase (ALT),aspartate aminotransferase(AST),laminin(LN) and hyaluronic acid(HA) in serum of rats in the JGZD group were significantly decreased;the levels of albumin(ALB) and total protein(TP) in serum of rats in the JGZD group were significantly increased.All the above differences were statistically significant(P＜0.05).The histopathological results showed that JGZD could obviously alleviate the pathological damage of the liver.Conclusion:JGZD can alleviate the damage of the liver and reduce the degree of fibrosis of model rats.关键词
加味膈下逐瘀汤/肝纤维化/肝功能/层粘连蛋白/透明质酸/大鼠Key words
Jiawei Gexia Zhuyu decoction/liver fibrosis/liver function/laminin/hyaluronic acid/rat分类
医药卫生引用本文复制引用
赵海军,李燕,赵鲁鸣,张亚楠,韩晓春,王媛,王世军..加味膈下逐瘀汤对肝纤维化模型大鼠肝功能及纤维化指标的影响[J].山东中医杂志,2017,36(5):407-410,4.基金项目
山东省中医药科技发展计划项目(编号:2011-009) （编号:2011-009）
山东省自然科学基金项目(编号:ZR2012HQ040) （编号:ZR2012HQ040）
