山东医药2017，Vol.57Issue(19)：25-28,4.DOI:10.3969/j.issn.1002-266X.2017.19.007
脓毒症患者内皮细胞蛋白C受体基因rs867186A/G位点多态性观察
Polymorphism of endothelial protein C receptor gene rs867186A/G in patients with sepsis
摘要
Abstract
Objective To observe the polymorphism of endothelial protein C receptor (EPCR) gene rs867186A/G in the peripheral blood of patients with sepsis.Methods Sixty-four patients with sepsis (sepsis group, male 38, female 26) and 113 healthy subjects (control group) were selected.We collected 5 mL peripheral blood samples from both the observation group and the control group.The polymorphisms of EPCR gene rs867186A/G in the peripheral blood were observed, and serum soluble EPCR (sEPCR) of two groups was measured by ELISA.Meanwhile, we investigated the effect of EPCR gene rs867186A/G polymorphisms on plasma sEPCR level and sepsis severity.Results The frequencies of AA, AG and GG genotypes and A ,G alleles were 81.2%, 17.2%, 1.6%, 89.8% and 10.2% respectively, in sepsis group, versus 83.2%, 16.8%, 0, 91.6% and 8.4% in control group, and there was no significant difference in frequency distribution of the above genotypes and alleles of two groups (all P>0.05).Males carrying rs867186 A allele of EPCR gene were associated with a significantly increased risk of sepsis than women carrying the same alleles (OR=1.735, 95% CI: 1.063-2.833, P<0.05).The plasma sEPCR level in the sepsis group was slightly higher than that in the control group but no significant difference was found (all P>0.05).There was no significant difference in plasma sEPCR level and severity of sepsis between patients with different rs867186A/G genotypes (all P>0.05).Conclusions The AA genotype or A allele is more frequently found in EPCR gene rs867186A/G in the peripheral blood of patients with sepsis.The polymorphism of EPCR gene rs867186A/G may be associated with the increased risk of sepsis.关键词
脓毒症/内皮细胞蛋白C受体/基因多态性Key words
sepsis/endothelial protein C receptor/gene polymorphism分类
医药卫生引用本文复制引用
梁燕冰,覃月秋,蒋玉洁,黄霞,李军,彭丁伟,黄雨晴,廖品琥..脓毒症患者内皮细胞蛋白C受体基因rs867186A/G位点多态性观察[J].山东医药,2017,57(19):25-28,4.基金项目
国家自然科学基金资助项目(81560321) （81560321）
2014年广西医学高层次骨干人才培养"139"计划培养人选项目 （）
广西高校急重症分子免疫研究重点实验室项目(yy2015ky002) （yy2015ky002）
广西研究生教育创新计划项目(YCSZ2015222). （YCSZ2015222）
