世界中医药2017，Vol.12Issue(5)：1081-1084,4.DOI:10.3969/j.issn.1673-7202.2017.05.033
异甘草酸镁联合白芍总苷治疗类风湿关节炎并肝功能异常的疗效及对免疫功能和肝功能的影响
Efficacy of Magnesium Isoglycyrrhizinate Combined with Total Glucosides of Peony in the Treatment of Rheumatoid Arthritis with Hepatic Dysfunction and Its Effect on Immune and Liver Function
摘要
Abstract
Objective: To study the clinical efficacy of magnesium isoglycyrrhizinate combined with total glucosides of peony (TGP) in the treatment of rheumatoid arthritis (RA) with hepatic dysfunction and its effect on immune and liver function.Methods: A total number of 76 RA patients with hepatic dysfunction were randomly divided into treatment group and control group, 38 cases in each group.The treatment group was treated with magnesium isoglycyrrhizinate combined with TGP and the control group was treated with conventional energy mixture.Both groups were treated for 14 days consecutively.Changes in immune function, liver function and serum RA were compared before and after treatment, and the incidence of adverse reactions was analyzed.Results: DAS28 in the treatment group was significantly lower than that before the treatment and of the control group (P<0.01).There was no significant difference in morning stiffness time, swelling joints number, tender joints number, grip strength and HAQ score between the two groups (P>0.05).After the treatment, serum IgE, sIL-2R, ALT and AST levels in the two groups were significantly lower and the treatment group was superior to the control group (P<0.01).The levels of CRP and TNF-α in the treatment group after the treatment were significantly lower than those before treatment and in the control group (P<0.05;P<0.01).No serious adverse reaction was detected in the two groups.Conclusion: Magnesium isoglycyrrhizinate combined with TGP may improve the immune function and liver function of patients with hepatic dysfunction and RA activity without obvious adverse reactions, which is worthy of clinical application.关键词
类风湿关节炎/异甘草酸镁/白芍总苷/免疫功能/肝功能Key words
Rheumatoid arthritis/Magnesium isoglycyrrhizinate/Total glucosides of peony (TGP)/Immune function/Liver Function分类
医药卫生引用本文复制引用
王淼,杨盼..异甘草酸镁联合白芍总苷治疗类风湿关节炎并肝功能异常的疗效及对免疫功能和肝功能的影响[J].世界中医药,2017,12(5):1081-1084,4.基金项目
河南省自然科学研究计划项目(编号:201310471055) （编号:201310471055）
