世界中医药2017，Vol.12Issue(5)：1200-1203,1208,5.DOI:10.3969/j.issn.1673-7202.2017.05.058
阿尔茨海默病发病机制及药物治疗研究进展
Progress in Mechanism of Pathogenesis and Medical Treatment of Alzheimer′s Disease
摘要
Abstract
Alzheimer′s disease (Alzheimer disease, AD) is a neurodegenerative disease of which etiology and pathogenesis has not been fully elucidated.Its symptoms are decreased memory and daily behavior capacity loss, cognitive impairment and personality changes.The pathogenesis are divergent, including micro environment related A beta amyloid cascade hypothesis, cholinergic damage theory, the abnormal immune theory, associated with neuronal Tau protein hypothesis, neural cell apoptosis theory, genes associated with apolipoprotein epsilon 4 gene, presenilin 1 and presenilin 2 gene and amyloid precursor protein gene.The western medicine treatment includes acetylcholinesterase inhibitor, reduced beta amyloid (A beta) generation, drug deposition, antioxidants and others.The traditional Chinese medicine treatment includes tonic drugs, living blood stasis drugs, eliminating phlegm and relieving asthma drugs.This article reviews the research progress of the pathogenesis and drug treatment of AD in recent years at home and abroad.关键词
阿尔茨海默病/发病机制/药物治疗/研究进展/综述Key words
Alzheimer′s disease/Pathogenesis/Drug therapy/Research progress/Review分类
医药卫生引用本文复制引用
张琳琳,宋宛珊,王凯,孙伟明,王一夫..阿尔茨海默病发病机制及药物治疗研究进展[J].世界中医药,2017,12(5):1200-1203,1208,5.基金项目
国家自然科学基金项目(编号:81202654)——益肾化浊法通过ngn1基因竞争性调控NSCs向神经元分化及其表观遗传学机制研究 （编号:81202654）
国家中医药管理局项目(编号:SATCM-2015-BZ273)——中医治未病实践指南-早期记忆力减退 （编号:SATCM-2015-BZ273）
