生命科学研究2017，Vol.21Issue(2)：95-100,6.DOI:10.16605/j.cnki.1007-7847.2017.02.001
人P2X1蛋白生物信息预测
Bioinformatic Analysis of Human P2X1 Protein
摘要
Abstract
Bioinformatics was used to predict the physicochemical properties,signal peptide,transmembrane domain,hydrophilicity/hydrophobicity,secondary and tertiary structures,protein-protein interaction and gene ontology (GO) of ligand-gated ion channel receptor P2X1 in humans.The results showed that P2X1 protein is a hydrophilic protein with two transmembrane domains,and consists of 399 amino acids.The isoelectric point of P2X1 protein is 8.75.The protein has a section of nuclear location sequence.The secondary structure analysis showed that it contains 6 α helices and 15β sheets.The reliability of predicted three-dimensional structure of human P2X1 was up to 45.35％.The predicted structure was stable by Ramachandran plot analysis.The proteins interacting with P2X1 were purinergic receptors and cation channels which act as signal transduction factors.The P2X1 protein can take part in some physiological processes such as intravascular coagulation,inflammation and so on.The predicted results provide important messages for further study of P2X1's effects in physiological processes and clinical treatment.关键词
P2X1蛋白/配体门控离子通道受体/血管凝集/炎症反应/生物信息学Key words
P2X1 protein/ligand-gated ion channel receptor/vascular agglutination/inflammatory response/bioinformatics分类
生物科学引用本文复制引用
魏梅,张连民,周蒙,李伟,董秋萍,许世磊..人P2X1蛋白生物信息预测[J].生命科学研究,2017,21(2):95-100,6.基金项目
国家自然科学基金资助项目(81301711) （81301711）
