生命科学研究2017，Vol.21Issue(2)：174-178,188,6.DOI:10.16605/j.cnki.1007-7847.2017.02.014
柯萨奇B3病毒性心肌炎的免疫抗炎症研究
The Immune and Anti-inflammatory Treatment of Coxsackie B3 Viral Myocarditis
摘要
Abstract
Viral myocarditis (VMC) is an infectious cardiac disease caused by multiple viruses,among which Coxsackie virus B3 (CVB3) is the most common.The typical manifestations of VMC are myocardial injury and necrosis caused by cardiomyocyte inflammatory responses,and eventually progressing to chronic inflammation or dilated cardiomyopathy,with high rates of morbidity and mortality in humans.At present,anti-inflammatory treatment of Coxsackie B3 viral myocarditis is still unsatisfactory,and the relevant immune anti-inflammatory mechanism is not fully elucidated.Exploring its immune and anti-inflammatory mechanism may be an important target for its treatment.Therefore,the latest immune and anti-inflammatory studies on Coxsackie B3 viral myocarditis were reviewed from six aspects,including the effects of Wnt1 1 gene,macrophages,galectin-3,zinc-finger antiviral protein,melittin and valproic acid.关键词
柯萨奇B3病毒性心肌炎/Wnt11基因/巨噬细胞/半乳糖凝集素3(Gal-3)/锌指抗病毒蛋白(ZAP)/蜂毒素/丙戊酸(VPA)Key words
Coxsackie B3 viral myocarditis/Wnt11 gene/macrophage/galectin-3 (Gal-3)/zinc-finger antiviral protein (ZAP)/melittin/valproic acid (VPA)分类
医药卫生引用本文复制引用
蔡悦,康永波,张宏..柯萨奇B3病毒性心肌炎的免疫抗炎症研究[J].生命科学研究,2017,21(2):174-178,188,6.基金项目
云南省科技厅项目(2013FC007) （2013FC007）
