三峡大学学报（自然科学版）2017，Vol.39Issue(3)：108-112,5.DOI:10.13393/j.cnki.issn.1672-948X.2017.03.024
骨疏颗粒对去势雌性大鼠骨关节炎的影响观察
Experimental Study of Effects of Gushu Granules on Osteoarthritis of Ovariectomized Osteoporotic Model Rats
摘要
Abstract
Objective To investigate the effect of Gushu granules on osteoarthritis ovariectomized osteoporotic model rats.In order to provide experimental basis for clinical application of Gushu granules and further study.60 SD rats were randomly divided into 4 groups i.e.model group,normal control group,estrogen group and group of Gushu granules.The osteoporosis model was induced by ovariectomy and overexercise.the change of sex hormone and inflammatory factor in rads were observed after the rats were treated with Gushu granules and estradiol valerate.The experimental results show Gushu granules and estradiol valerate could increase the level of sex hormone and reduce inflammatory factor of osteoarthritis model rats(P＜0.01 or P＜ 0.05).Significant difference is compared with model group (P＜0.05).There is no significant difference between the two(P＞0.05).It is concluded that the Gushu granules could treatment and delay osteoarthritis.There is no significant difference with estradiol valerate.关键词
骨关节炎/骨疏颗粒/IL-1/IL-6/TNF-α/实验研究Key words
osteoarthritis/Gushu granules/IL-1/IL-6/TNF-α/experimental study分类
医药卫生引用本文复制引用
李冰,杜义斌..骨疏颗粒对去势雌性大鼠骨关节炎的影响观察[J].三峡大学学报（自然科学版）,2017,39(3):108-112,5.基金项目
云南省教育厅科学研究基金项目(课题号:2014Z124) （课题号:2014Z124）
云南省卫生科技计划项目(课题号:2014NS334) （课题号:2014NS334）
