现代妇产科进展2017，Vol.26Issue(5)：342-344,348,4.DOI:10.13283/j.cnki.xdfckjz.2017.05.006
新一代杂交捕获技术在宫颈癌筛查中的应用
Application of a new generation of hybrid capture technology in cervical cancer screening
摘要
Abstract
Objective:To compare the advantages of domestic HPV hybrid capture technology (DH2) in cervical cancer screening and traditional screening methods.To explore the clinical significance of HPV16/18 genotyping in the triage management of patients with DH2 positive screening.To provide a feasible and effective theoretical basis for the promotion and improvement of large-scale cervical cancer screening in rural areas.Methods:In 2013,2014 and 2015,79847,81702,and 61072 women were screened for cervical cancer by Pap smear separately.In 2015 and 2016,35657 and 59634 women screened for cervical cancer by 14 high-risk HPV detection respectively.The pathological diagnosis as the gold standard,analysis the rate of Low-grade Squamous Intraepithelial Lesion (LSIL) and above with high-risk HPV detection method and Pap smear.DH2 positive patients were detected by HPV16/18,and compared with the detection of HPV16/18 shunt strategy.Result:In 2013,2014 and 2015,the detection rates of LSIL and above were 0.048%,0.105% and 0.134% with Pap smear,respectively.In 2015 and 2016,the detection rates of LSIL and above were 0.415% and 0.550% with high-risk HPV detection,respectively.In 2015,DH2 as primary screening,the positive rates of LSIL and above in DH2 positive and HPV16/18 positive were 4.644% and 15.370%,respectively.In 2016,DH2 positive patients with HPV16/18 detection as primary screening,the positive rates of LSIL and above in DH2 positive and HPV16/18 positive were 6.365% and 22.430%,respectively.Conclusions:Compared with the traditional detection methods,the detection rate of cervical precancerous lesions by DH2 detection is higher.DH2 positive patients with HPV16/18 detection as primary screening can further improve the detection rate of LSIL and above disease in cervical cancer screening.关键词
HPV/宫颈癌/检出率/筛查/分流Key words
HPV/Cervical cancer/Detection rate/Screening/Shunt分类
医药卫生引用本文复制引用
余向红,卢雁,陈淑群,邵志叶..新一代杂交捕获技术在宫颈癌筛查中的应用[J].现代妇产科进展,2017,26(5):342-344,348,4.
