中国组织工程研究2017，Vol.21Issue(13)：2127-2132,6.DOI:10.3969/j.issn.2095-4344.2017.13.026
人羊膜间充质干细胞治疗急性肺损伤的研究与进展
A review of human amniotic mesenchymal stem cells in the treatment of acute lung injury
摘要
Abstract
BACKGROUND:In recent years, with the in-depth research on the characteristics and functions of stem cells,stem cell research has become a hot research targeting the treatment of a variety of diseases.OBJECTIVE:To summarize the research progress of human amniotic mesenchymal stem cells in the treatment of acute lung injury.METHODS:The PubMed and CNKI databases were searched by computer for relevant literatures published from January 2000 to January 2017. The key words were "mesenchymal stem cells, acute lung injury" in Chinese and English,respectively.RESULTS AND CONCLUSION:As an important member of adult stem cells, human amniotic mesenchymal stem cells not only have the advantages and characteristics of most other stem cells, but also have unique advantages, such as these cells can be extracted from a vast of sources, require only non-invasive operations, and involve no violation of ethics. Human amniotic mesenchymal stem cells can be driven by inflammation reaction and homing to the damaged tissue, and be activated by inflammatory factors to secrete a variety of cytokines in a paracrine fashion, which inhibit neutrophils, macrophages and other immune cell migration and inhibit dendritic cell maturity, and reduce the proliferation of NK cells, B lymphocytes and T lymphocytes, and up-regulate anti-inflammatory cytokines and down-regulate proinflammatory cytokines, and alleviate alveolar inflammatory injury through anti-oxidation and anti-apoptotic processes. Human amniotic mesenchymal stem cells can also assist in the repair or homing to the damaged tissue to directionally differentiate to replace the apoptotic and necrotic cells. All of these characteristics of human amniotic mesenchymal stem cells provide new insight into the treatment of acute lung injury. As acute lung injury is caused by many pathogenic factors and its pathophysiological process is very complicated, human amniotic mesenchymal stem cell transplantation in the treatment of acute lung injury has many issues to be resolved.关键词
干细胞/移植/人羊膜间充质干细胞/急性肺损伤/细胞因子/综述分类
医药卫生引用本文复制引用
唐明美,赵建军,曹志敏,文强,何月娟,陈玲..人羊膜间充质干细胞治疗急性肺损伤的研究与进展[J].中国组织工程研究,2017,21(13):2127-2132,6.基金项目
贵州省科技计划课题(黔科合SY字[2015]3050):急性肺损伤病人肺保护的临床研究 （黔科合SY字[2015]3050）
the Scientific Research Plan Project of Guizhou Province, No. [2015]3050 （）
