中国组织工程研究2017，Vol.21Issue(14)：2133-2139,7.DOI:10.3969/j.issn.2095-4344.2017.14.001
钽棒置入与腓骨支撑修复早期股骨头坏死
Tantalum rod implantation versus fibular fixation in the treatment of osteonecrosis of the femoral head at early stage
摘要
Abstract
BACKGROUND: Fibular fixation and tantalum rod implantation are two commonly used methods for the treatment of early osteonecrosis of the femoral head (ONFH), both of which can effectively delay or even reverse the progress of ONFH. However, further comparative evaluation on their mechanical properties and therapeutic efficacy is required.OBJECTIVE: To compare the clinical efficacy of fibular fixation and tantalum rod implantation on ONFH at early stage.METHODS: Fifty-eight patients (81 hips) suffered from ONFH with ARCO stage 1 and stage 2, and underwent fibular fixation (30 cases, 41 hips) or tantalum rod implantation (28 cases, 40 hips). Postoperatively, both groups were followed up for over 2 years. The Harris scores of the hip were compared between two groups before and after treatment. With femoral head collapse and the collapse distance > 4 mm as observation points, the survival rate of the femoral head was compared between two groups.RESULTS AND CONCLUSION: The postoperative Harris scores of the two groups were significantly improved than before (P < 0.05). With the appearance of femoral head collapse as the observation point, the Kaplan-Meier survival curve showed that the overall survival rate of the hip was 83% in the fibular fixation group and 65% in the tantalum rod implantation group. After examined by log-rank (Mantel-Cox), there was a significant difference in the survival rate of the hip at Stage IIC between two groups (P=0.0431). With > 4 mm collapse as the observation point, the Kaplan-Meier survival curve showed that overall survival rate of the hip was 95% in the fibular fixation group and 83% in the tantalum rod implantation group. After examined by log-rank (Mantel-Cox), there was a significant difference in the survival rate of the hip at Stage IIC between two groups (P=0.0418). To conclude, both fibular fixation and tantalum rods implantation applied to ONFH at early stage can effectively improve the hip function, and the survival rate of the hip at ARCO Stage IIC is better in patients undergoing fibular fixation than tantalum rod implantation.关键词
生物材料/骨生物材料/股骨头坏死/早期/腓骨支撑术/钽棒置入术/股骨头塌陷/生存率/疗效比较/国家自然科学基金分类
医药卫生引用本文复制引用
杨开,曾平,欧志学,赖崇荣,黄海滨,刘明伟,黄肖华,何伟..钽棒置入与腓骨支撑修复早期股骨头坏死[J].中国组织工程研究,2017,21(14):2133-2139,7.基金项目
国家自然科学基金项目(81360551) （81360551）
广西科学研究与技术开发计划项目(桂科攻1140003B-57) （桂科攻1140003B-57）
广西医疗卫生重点科研课题(重2011053)Funding: the National Natural Science Foundation of China, No. 81360551 （重2011053）
the Science Research and Technology Development Project of Guangxi Province, No. 1140003B-57 （）
the Medical and Health Research Project of Guangxi Province, No. 2011053 （）
