中国组织工程研究2017，Vol.21Issue(14)：2266-2273,8.DOI:10.3969/j.issn.2095-4344.2017.14.022
骨组织工程支架材料在骨缺损修复及3D打印技术中的应用
Three-dimensional printing technology preparation of bone tissue engineering scaffold materials in bone defect repair
摘要
Abstract
BACKGROUND: Bone tissue engineering plays a very important role in the repair of bone defects, which can deliver bioactive substances, promote bone tissue growth and repair bone defects. Bone scaffolds act as one of the three elements of bone tissue engineering. Three-dimensional (3D) printing technology can achieve individualized bone tissue repair through customized artificial bone preparation.OBJECTIVE: To analyze the biological characteristics of several commonly used bone tissue engineering scaffolds and to explore the application of 3D printing technique in the construction of bone tissue engineering scaffolds.METHODS: The literatures of PubMed and Wanfang database related to bone tissue engineering scaffold materials and 3D printing technology were retrieved from 2005 to 2016. The Keywords were "tissue engineering scaffold, bone defects,polymer materials, bioceramics, metal materials, composite materials, 3D printing" in English and Chinese, respectively,which would appear simultaneously in title and abstract. Repetitive articles were excluded and finally 65 articles were included in result analysis.RESULTS AND CONCLUSION: The commonly used bone tissue engineering scaffold materials include polymer materials (natural and macromolecule polymeric materials), bioceramics, and metal materials. According to the characteristics of the materials, composite materials made of different materials can compensate for the shortcomings of a single material, and then developed into new tissue engineering scaffold materials. For the tissue engineering bone production, 3D printing technologies include melt deposition technology, selective laser sintering technology, low temperature deposition manufacturing technology, and etc. When the 3D printing technology is used to prepare a bone tissue engineering scaffold, the use of powder or adhesive must have limited conditions, such as flowability, stability and wettability. Powder materials used for 3D printing can be divided into synthetic polymers, natural macromolecules,bioceramics and their mixtures, with different advantages and disadvantages. Ultimately, the bone engineering scaffolds produced by 3D printing technology have unique advantages in mechanics, structure and individuality, and have wide application prospect in the manufacture of bone scaffolds.关键词
生物材料/骨生物材料/生物支架材料/骨组织工程/骨缺损/骨组织修复/3D打印技术/个性化定制分类
医药卫生引用本文复制引用
党莹,李月,李瑞玉,吴立萍,郭雅静,宋瑞佳..骨组织工程支架材料在骨缺损修复及3D打印技术中的应用[J].中国组织工程研究,2017,21(14):2266-2273,8.基金项目
河北省中医药管理局资助项目(2012068) Funding: the Funded Project of Hebei Provincial Administration of Traditional Chinese Medicine, No. 2012068 （2012068）
