中国组织工程研究2017，Vol.21Issue(14)：2280-2284,5.DOI:10.3969/j.issn.2095-4344.2017.14.024
蚕丝丝素蛋白/壳聚糖支架在骨科再生医学中的作用与特点
Application and characteristics of silk fibroin/chitosan scaffold in orthopaedic regenerative medicine
摘要
Abstract
BACKGROUND: A silk fibroin/chitosan scaffold has good biocompatibility, osteoinductivity and degradability.OBJECTIVE: To review the structure, performance and application of the silk fibroin/chitosan scaffold in bone,cartilage and soft tissue engineering regeneration.METHODS: PubMed, Wanfang, and CNKI databases were retrieved by computer for articles related to the structure, performance and application of the silk fibroin/chitosan scaffold in orthopedics published from 1998 to 2016. The keywords were "chitosan, silk protein, bone tissue engineering" in English and Chinese, respectively.RESULTS AND CONCLUSION: The silk fibroin/chitosan scaffold is characterized by good biocompatibility, bone inductivity and biodegradability that make cells grow well on the scaffold. The silk fibroin/chitosan scaffold has been widely used in bone tissue engineering, and has a prominent performance in bone defect repair and cartilage injury treatment. Meanwhile, the silk fibroin/chitosan scaffold exerts a crucial role in wound healing as well as in the treatment of spinal nerve injury and other soft tissue injuries. However, the silk fibroin/chitosan scaffold currently is less reported in the clinical use due to various reasons, and it will be the main research direction of future efforts. As is known to us, silk protein can be used to prepare the cruciate ligament and construct tissue-engineered nuclei; therefore, the silk fibroin/chitosan scaffold can be developed in the treatment of tendon ligament injury and intervertebral disc tissue engineering.关键词
生物材料/骨生物材料/壳聚糖/丝素蛋白/骨组织工程/支架材料/广西壮族自治区自然科学基金分类
医药卫生引用本文复制引用
袁振中,陈跃平..蚕丝丝素蛋白/壳聚糖支架在骨科再生医学中的作用与特点[J].中国组织工程研究,2017,21(14):2280-2284,5.基金项目
广西卫生适宜技术研究与开发项目(S201419-5) （S201419-5）
广西自然科学基金项目(2015GXNSFAA139136) （2015GXNSFAA139136）
广西高校青年教师基础能力提升项目(KY2016YB204) （KY2016YB204）
广西中医药大学校级科研项目(2015LX027) （2015LX027）
2014年广西中医药大学校级培育学科-骨外科学建设项目[J13167(7)] Funding: the Health Technology Research and Development Project of Guangxi Zhuang Autonomous Region, No.S201419-5 （7）
the Natural Science Foundation of Guangxi Zhuang Autonomous Region, No. 2015GXNSFAA139136 （）
the Basic Ability Improvement Project of Young Teachers in Guangxi Colleges and Universities, No. KY2016YB204 （）
the Scientific Research Project of Guangxi University of Chinese Medicine, No. 2015LX027 （）
the Training Discipline-Bone Surgery Construction Project of Guangxi University of Chinese Medicine in 2014, No. J13167(7) （7）
