中国组织工程研究2017，Vol.21Issue(15)：2325-2330,6.DOI:10.3969/j.issn.2095-4344.2017.15.006
置入碳纤维增强聚醚醚酮股骨头假体稳定性的生物力学分析
Carbon fiber-reinforced polyetgeretherketone for femoral head prosthesis and its stability:a biomechanical analysis
摘要
Abstract
BACKGROUND: Metal implants have been extensively applied in joint arthoplasty, but the stress shielding effect caused by its high elastic modulus results in a series of complications, such as bone resorption, bone atrophy and prosthesis loosening. Carbon fiber-reinforced polyetheretherketone (CF-PEEK) composites are anisotropic and exhibit more advantages used for prosthesis due to its low elastic modulus and high intensity.OBJECTIVE: To investigate the blood compatibility of CF-PEEK composites, and compare the biomechanical properties after arthroplasty between CF-PEEK composites and Co-Cr-Mo used for femoral head prosthesis. METHODS: (1) The blood compatibility of CF-PEEK composites was evaluated through hemolysis test. (2) Femoral samples from eight fresh cadavers were collected and randomly divided into two groups, followed by subjected to CF-PEEK and Co-Cr-Mo prosthesis replacement, respectively. The displacement between the prosthesis and bone was measured under loading 200, 400, 600, 800 and 1000 N, and the torsional strength after arthroplasty was detected.RESULTS AND CONCLUSION: (1) The hemolysis rate of the CF-PEEK composites was 3.23% < 5%, which was in line with the national standards for biological evaluation of medical devices. (2) The micromovement in distal prosthesis was significantly less than that of proximal prosthesis under different loads in both two groups (P < 0.05). (3) The torsion angle under different loads in the CF-PEEK group was significantly less than that in the Co-Cr-Mo group (P < 0.05), and the torsion stiffness in the CF-PEEK group was significantly higher than that in the Co-Cr-Mo group (P < 0.05). (4) To conclude,the CF-PEEK composites possess good blood compatibility and stability, which can be used as a prosthesis material.关键词
骨科植入物/人工假体/股骨头/关节假体/关节置换/碳纤维增强聚醚醚酮/复合材料/钴铬钼合金/血液相容性/稳定性/海南省自然科学基金分类
医药卫生引用本文复制引用
纪志华,贾丙申,周立义,付昆,孟志斌,于鹏,云大科..置入碳纤维增强聚醚醚酮股骨头假体稳定性的生物力学分析[J].中国组织工程研究,2017,21(15):2325-2330,6.基金项目
海南省自然科学基金资助项目(814357)the Natural Science Foundation of Hainan Province, No. 814357Funding: the Natural Science Foundation of Hainan Province, No. 814357 （814357）
