中国组织工程研究2017，Vol.21Issue(15)：2418-2423,6.DOI:10.3969/j.issn.2095-4344.2017.15.022
3D打印应用在骨组织工程研究中的特点与进展
Characters and progress of three-dimensional printing technology in bone tissue engineering
摘要
Abstract
BACKGROUND: Individual three-dimensional (3D) scaffolds can be constructed by 3D printing via Computer Aided Design based on the given anatomical measurements of related tissues. A rapid and accurate reconstruction of bone, cartilage, muscle and vessel also can be achieved by 3D printing; however, many problems still remain unsolved.OBJECTIVE: To summarize the principle and classification of 3D printing, the classification, characteristics and histocompatibility of scaffolds through reviewing the articles addressing 3D printing applied in bone tissue engineering,thereby providing theoretical foundation for the study on the construction of tissue-engineered bone.METHODS: PubMed and CNKI databases were retrieved for the literatures regarding the application of 3D printing technology in bone tissue engineering published from January 2001 to January 2017 using the keywords of "three-dimensional printing, rapid prototyping manufacturing, bone tissue engineering" in English and Chinese,respectively. Finally, 30 articles were reviewed and discussed in accordance with the inclusion and exclusion criteria.RESULTS AND CONCLUSION: The microstructures of normal tissues can be reconstructed and seed cells are printed on the 3D scaffolds synchronously by 3D printing technology. Moreover, the scaffold degradation and cell differentiation are synchronous, which contributes to tissue repair. Biological ceramics have been widely used in bone tissue engineering because of its good biocompatibility and mechanical properties. However, the urgent problems such as angiogenesis and cellular signal transduction still need to be addressed.关键词
骨科植入物/骨植入物/快速成型技术/3D打印/骨组织工程分类
医药卫生引用本文复制引用
武成聪,王芳,荣树,吴铮,刘涛,刘克廷,朱博,黄合飞..3D打印应用在骨组织工程研究中的特点与进展[J].中国组织工程研究,2017,21(15):2418-2423,6.基金项目
云南省教育厅科学研究基金项目(2016ZDX074)the Research Foundation of the Department of Education of Yunnan Province, No. 2016ZDX074 （2016ZDX074）
